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FLASH GENE
Symbol ADRB2 contributors: mct - updated : 09-03-2016
HGNC name adrenergic, beta-2-, receptor, surface
HGNC id 286
Location 5q32      Physical location : 148.206.155 - 148.208.196
Synonym symbol(s) ADRB2R, ADRBR, B2AR, BAR2
DNA
TYPE functioning gene
STRUCTURE 2.04 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map see CSF1R ,IRF1
Physical map
DPYSL3 5q32 dihydropyrimidinase-like 3 KIAA0555 5q32 dihydropyrimidinase-like 3 SPINK1 5q31 serine protease inhibitor, Kazal type 1 LOC391838 5 similar to low affinity N-formyl peptide receptor SCGB3A2 5q32 secretoglobin, family 3A, member 2 LOC389336 5 similar to AVLV472 LOC391839 5 similar to elongation factor 1 gamma SPINK5 5q32 serine protease inhibitor, Kazal type, 5 LOC340060 5q33.1 similar to alpha-5 collagen ECG2 5q33.1 similar to alpha-5 collagen FLJ13962 5q33.1 hypothetical protein FLJ13962 SP329 5q33.1 hypothetical protein SP329 HTR4 5q31-q33 5-hydroxytryptamine (serotonin) receptor 4 ADRB2 5q31.3 adrenergic, beta-2-, receptor, surface KIAA1985 LOC255187 5q33.1 hypothetical LOC255187 KIAA0843 FLJ36748 5q33.1 hypothetical protein FLJ36748 GRPEL2 5q33.1 GrpE-like 2, mitochondrial (E. coli) MGC3265 5q33.1 hypothetical protein MGC3265 IL17B 5q32-34 interleukin 17B CSNK1A1 13q13 casein kinase 1, alpha 1 LOC389337 5 similar to hypothetical protein 4933429F08 PERC 5q33.1 similar to hypothetical protein 4933429F08 PDE6A 5q31.3 phosphodiesterase 6A, cGMP-specific, rod, alpha SLC26A2 5q31.3 solute carrier family 26 (sulfate transporter), member 2 TIGD6 5q32 tigger transposable element derived 6 RPS20P4 5q33-qter ribosomal protein S20 pseudogene 4 CSF1R 5q31.3 colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog RPL7P 5q33.3 ribosomal protein L7 pseudogene PDGFRB 5q31.3 platelet-derived growth factor receptor, beta polypeptide CDX1 5q31.3 caudal type homeo box transcription factor 1 SLC6A7 5q31-q32 solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 CAMK2A 5q33.2 calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 2058 - 413 - 1997 9339364
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart     Homo sapiens
Nervousbrainhindbrainmedulla oblongata  
Reproductivefemale systemplacenta   
Visualeyeretina   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Muscularstriatumcardiac   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Muscularmyocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PDZ binding motif
  • C terminus distal to AA 381 does not affect the initial interaction between receptor and beta-arrestin, but its last eight AAs facilitate receptor internalization in concert with ARRB2 (
  • HOMOLOGY
    Homologene
    FAMILY G protein coupled receptor superfamily
    CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • major lipolytic receptor in human fat cell, activating adenylate cyclase
  • ADRB2, ADRA1B in bone cells may play a role in modulation of bone turnover by the sympathetic nervous system
  • seven transmembrane segments (7TM) receptor, polymorphic, with a 5' leader region made of a short ORF, potentially involved in the regulation of cellular ADRBL expression
  • mediating the catecholamine-induced activation of adenylate cyclase through the action of G proteins
  • may be involved in the cardioprotection against ischemic damage, and the cardioprotection may depend on estrogenic environment
  • playing an essential role in signaling and trafficking in cardiac myocytes
  • on the surface of cardiomyocytes mediate distinct effects on cardiac function and the development of heart failure by regulating production of the second messenger cyclic adenosine monophosphate (cAMP)
  • potential involvement in diabetic cardiomyopathy
  • mediates obesity, cardiorespiratory fitness, and insulin resistance
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with NEDD4 (NEDD4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the ADRB2)
  • ADRB2 is a novel target of PPARgamma transcriptional repression in vascular smooth muscle cells (PPARgamma regulation of ADRB2 signaling is important in the modulation of blood pressure)
  • MARCH2 catalytic activity is not required for its interaction with the ADRB2 and loss of activity creates a “substrate trap” leading to a stable complex formation between the two molecules
  • interaction between RNF5 and the ADRB2 as well as the prostaglandin D2 receptor (DP)
  • SSTR2 plays a crucial role in modulation of ADRB1 and ADRB2 mediated signaling pathways that are associated with increased intracellular Ca(2+) and cardiac complications
  • ubiquitination by the E3 ligase NEDD4 and deubiquitination by the deubiquitinases USP20 and USP33 have been shown to regulate the lysosomal trafficking and recycling of agonist-activated ADRB2
  • cell & other
    REGULATION
    Other is modified at a second site within the third intracellular loop
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    is potentially implicated in diabetic cardiomyopathy
    constitutional     --over  
    in lymphatic malformations
    constitutional     --over  
    ADRB2, FOLR3 and GSTM1 were upregulated in the monocytes of patients with early onset coronary artery disease
    Susceptibility
  • to nocturnal asthma, to non insulin dependent diabetes
  • to type 2 diabetes mellitus (T2DM) in obese, postmenopausal women
  • to chronic obstructive pulmonary disease (COPD)
  • Variant & Polymorphism SNP , other
  • polymorphism, R16G
  • 27 Glu polymorphism interacting with physical activity to influence female obesity risk
  • Gln27Gln polymorphism increases the risk of non insulin dependent diabetes
  • Arg16Gly influencing the pathophysiology of OAG in Japanese patients
  • ADRB2 haplotypes may mediate insulin action, glucose tolerance, and potentially risk for type 2 diabetes mellitus (T2DM) in obese, postmenopausal women
  • Gly16 allele of ADRB2 predisposes to COPD development but not for exacerbation rates and disease severity
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabete  
    ADRB2 agonist ameliorates cardiac dysfunction suggesting that ADRB2 have crucial role in diabetic cardiomyopathy
    ANIMAL & CELL MODELS