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FLASH GENE
Symbol ADRA2A contributors: mct/npt - updated : 30-05-2018
HGNC name adrenergic, alpha-2A-, receptor
HGNC id 281
Location 10q25.2      Physical location : 112.836.789 - 112.840.660
Synonym name
  • alpha-2AAR subtype C10
  • alpha-2-adrenergic receptor, platelet type
  • Synonym symbol(s) ADRA2, ADRA2R, ADRAR, ZNF32, ALPHA2AAR
    DNA
    TYPE functioning gene
    STRUCTURE 3.65 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (TATA box)
    cytosine-phosphate-guanine/HTF
    Binding site   transcription factor
    text structure
  • two potential TATA box motifs TATATAT and TATAAAA, located 427 and 1037 base pairs (bp), respectively, upstream of the protein coding region (Handy 1992)
  • a GC box, a common motif for Sp1 nuclear factor binding (Handy (1992)
  • MAPPING cloned Y linked N status confirmed
    Physical map
    LOC390001 10 similar to mitogen-activated protein kinase-activated protein kinase LOC390002 10 similar to B-cell receptor-associated protein 37; repressor of estrogen receptor activity XPNPEP1 10q25.3 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble RNU4P5 10q25.2 RNA, U4 small nuclear pseudogene 5 ADD3 10q24.2-q24.3 adducin 3 (gamma) MXI1 10q25 MAX interacting protein 1 SMNDC1 10q23 survival motor neuron domain containing 1 DUSP5 10q25 dual specificity phosphatase 5 CSPG6 10q25 chondroitin sulfate proteoglycan 6 (bamacan) LOC340699 10q25.3 similar to 1110018J23Rik protein PDCD4 10q24 programmed cell death 4 (neoplastic transformation inhibitor) SHOC2 10q25 soc-2 suppressor of clear homolog (C. elegans) ADRA2A 10q25 adrenergic, alpha-2A-, receptor KIAA1560 10q25.3 glycerol 3-phosphate acyltransferase, mitochondrial TECTB 10q25-q26 tectorin beta LOC390003 10 similar to guanylyl cyclase with kinase-like domain, soluble FACL5 10q25.1-q25.2 fatty-acid-Coenzyme A ligase, long-chain 5 ZDHHC6 10q26.11 zinc finger, DHHC domain containing 6 VTI1A 10q26.11 vesicle transport through interaction with t-SNAREs homolog 1A (yeast) TCF7L2 10q25.3 transcription factor 7-like 2 (T-cell specific, HMG-box) FLJ23556 10q26.11 hypothetical protein FLJ23556 LOC390004 10 similar to peptidylprolyl isomerase E (cyclophilin E) HABP2 10q26.11 hyaluronan binding protein 2 NRAP 10q23-q26 nebulin-related anchoring protein CASP7 10q25.1-q25.2 caspase 7, apoptosis-related cysteine protease FLJ23537 10q26.11 hypothetical protein FLJ23537 DCLRE1A 10q25.1 DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae) FLJ25621 10q26.11 FLJ25621 protein FLJ20147 10q26.11 hypothetical protein FLJ20147 ADRB1 10q24.3 adrenergic, beta-1-, receptor FLJ10188 10q26.11 CTCL tumor antigen L14-2 TDRD1 10q24.1-q25.3 tudor domain containing 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 3889 - 465 - Handy (1992)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrinepancreas   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
  • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • adrenergic, alpha-2A-receptor, inhibiting formation of cAMP opening K+ channels, inhibiting Ca2+ channels
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to type 2 diabetes
  • to attention deficit hyperactivity disorder (Gizer 2009)
  • to decreased glucose-stimulated insulin response
  • Variant & Polymorphism SNP
  • a single-nucleotide polymorphism in the human ADRA2A gene for which risk allele carriers exhibited overexpression of alpha(2A)AR, reduced insulin secretion, and increased type 2 diabetes risk (Rosengren 2010)
  • variants at the DGKB/AGMO, ADRA2A, GLIS3 and C2CD4B loci were associated with decreased glucose-stimulated insulin response
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS