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FLASH GENE
Symbol ADRA1D contributors: mct - updated : 19-09-2018
HGNC name adrenergic, alpha-1D-, receptor
HGNC id 280
Location 20p13      Physical location : 4.201.277 - 4.229.659
Synonym symbol(s) DAR, ADRA1, ADRA1A, ADRA1R, ALPHA1
DNA
TYPE functioning gene
STRUCTURE 28.38 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
UBE2V1P1 20p13 ubiquitin-conjugating enzyme E2 variant 1 pseudogene 1 ATRN 20p13 attractin SF3A3P 20p13 splicing factor 3a, subunit 3 pseudogene GFRA4 20p13-p12 GDNF family receptor alpha 4 ADAM33 20p13 a disintegrin and metalloproteinase domain 33 SN 20p13 sialoadhesin HSPA12B 20p13 heat shock 70kD protein 12B C20orf27 20p13 chromosome 20 open reading frame 27 C20orf28 20pter-q11.23 chromosome 20 open reading frame 28 CENPB 20p13 centromere protein B, 80kDa CDC25B 20p13 cell division cycle 25B C20orf29 20p13 chromosome 20 open reading frame 29 KIAA1271 20p13 KIAA1271 protein PANK2 20p13 pantothenate kinase 2 (Hallervorden-Spatz syndrome) RNF24 20p13-p12.1 ring finger protein 24 LOC388783 20 similar to hypothetical protein RPL21P2 20p13 ribosomal protein L21 pseudogene 2 MGC34919 20p13 hypothetical protein MGC34919 SMOX 20p13 spermine oxidase ADRA1D 20p13 adrenergic, alpha-1D-, receptor RPL7AL2 20p13 ribosomal protein L7a like 2 RPS4L2 20p13 ribosomal protein S4-like 2 PRNP 20p12.3 prion protein (p27-30) (Creutzfeld-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia) PRND 20pter-p12 prion protein 2 (dublet) LOC149830 20p13 M8 protein RASSF2 20pter-p12.1 Ras association (RalGDS/AF-6) domain family 2 SLC23A2 5q31.2-q31.3 solute carrier family 23 (nucleobase transporters), member 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2666 - 572 - 2017 28862946
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainlimbic systemhippocampus   Homo sapiens
Reproductivefemale systembreastmammary gland moderately
 male systemprostate    Homo sapiens
 male systemtestis    Homo sapiens
 male systemseminal vesicles    Homo sapiens
 male systemmale genital tractepididymis   Homo sapiens
Urinaryureter     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM)
  • two N-linked glycosylation sites in its N terminus
  • a transmembrane region
  • several phosphorylation sites in its C terminus
  • conjugated GlycoP , LipoP
    HOMOLOGY
    interspecies ortholog to rattus Adra1d
    ortholog to murine Adra1d
    homolog to drosophila oamb
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • integral to plasma membrane
  • basic FUNCTION
  • mediating its effect through the influx of extracellular
  • calcium
  • acting through the phosphadidylinositol/Ca2+ second messenger system
  • mediating G1-S cell-cycle
  • is a key regulator of sympathetic nervous system function
  • syntrophin and utrophin associate with ADRA1D to create a functional signalosome, which is essential for ADRA1D regulation of vascular tone and blood pressure
  • ADRA1D expression is essential for skeletal muscle cell survival
  • cross-talk between ADARA1D and TRPV1, that is involved in the control of prostate carcinoma cell proliferation
  • G protein-coupled receptors that mediate adrenaline/noradrenaline actions
  • is a key regulator of cardiovascular, prostate, and central nervous system functions
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    text
  • positif regulation of cell proliferation
  • PATHWAY
    metabolism nucleic
    signaling signal transduction
  • DNA metabolism
  • cell-cell signaling
  • a component
  • modular dimeric architecture for the ADRA1D in the cell membrane
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • syntrophin, dystrobrevin, and utrophin as essential GPCR-interacting proteins for ADRA1D
  • induces vascular smooth muscle apoptosis via a TP53-dependent mechanism
  • inhibition of vascular smooth muscle ADRBK1 enhances ADRA1D-adrenergic receptor constriction
  • ADRA1D-a key regulator of cardiovascular, urinary and CNS function-binds the syntrophin family of PDZ domain proteins (SNTA, SNTB1, and SNTB2) through a C-terminal PDZ ligand interaction, ensuring receptor plasma membrane localization and G-protein coupling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    selective ADRA1B antagonist inhibits prostate cancer cell proliferation and motility
    ANIMAL & CELL MODELS