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FLASH GENE
Symbol ADORA3 contributors: npt/ - updated : 15-10-2007
HGNC name adenosine A3 receptor
HGNC id 268
Location 1p13.2      Physical location : 112.025.970 - 112.106.597
Synonym name AD026 protein
Synonym symbol(s) A3AR, AD026, bA552M11.5
DNA
TYPE functioning gene
STRUCTURE 80.63 kb     6 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 2161 - 347 - -
2 - 2261 36.2 318 - -
6 - 1185 - 266 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
Nervousbrain   highly
 nerve   highly
Reproductivemale systemtestis  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
    • conjugated GlycoP , LipoP
    HOMOLOGY
    interspecies ortholog to murine Adora3
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION
    text expressed weakly in the cytoplasm (Cui 2008)
    basic FUNCTION
  • adenosine receptor A3, activating adenylate cyclase
  • involved in signal amplification, controlling ATP gradient sensing and migration of neutrophils
  • protecting the ventricular heart cell against injury during a subsequent exposure to ischemia
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in peripheral blood mononuclear cells of rheumatoid arthritis patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS