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FLASH GENE
Symbol ADORA3 contributors: npt/ - updated : 15-10-2007
HGNC name adenosine A3 receptor
HGNC id 268
Location 1p13.2      Physical location : 112.025.970 - 112.106.597
Synonym name AD026 protein
Synonym symbol(s) A3AR, AD026, bA552M11.5
DNA
TYPE functioning gene
STRUCTURE 80.63 kb     6 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
LOC388664 1 similar to prochymosin KCNA10 1p13.1 potassium voltage-gated channel, shaker-related subfamily, member 10 KCNA2 1p13 potassium voltage-gated channel, shaker-related subfamily, member 2 KCNA3 1p13.3 potassium voltage-gated channel, shaker-related subfamily, member 3 LOC137829 1p13.2 similar to Nuclear receptor binding factor-2 CD53 1p13 CD53 antigen RIF1 1p13.2 receptor-interacting factor 1 MGC54289 1p13.2 hypothetical protein MGC54289 CEPT1 1p12 choline/ethanolaminephosphotransferase FLJ22457 1p13.2 hypothetical protein FLJ22457 CHI3L2 1p13.3 chitinase 3-like 2 LOC149620 1p13.2 similar to CHIA protein CHIA 1p21.3-p13.1 similar to CHIA protein LOC128344 1p13.2 hypothetical protein LOC128344 LOC388665 1 similar to DKFZP564K247 protein LOC391066 1 similar to pepsinogen B OVGP1 1p13 oviductal glycoprotein 1, 120kDa (mucin 9, oviductin) MEP50 1p13.2 MEP50 protein ATP5F1 1p12 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b, isoform 1 MGC24133 1p13.2 hypothetical protein MGC24133 AD026 1p13.1 AD026 protein ADORA3 1p13.3 adenosine A3 receptor RAP1A 1p13.3 RAP1A, member of RAS oncogene family LOC55924 1pter-q31.3 hypothetical protein LOC55924 DDX20 1p21.1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 KCND3 1p13.2 potassium voltage-gated channel, Shal-related subfamily, member 3 AF357532 1q12 thioredoxin 1 pseudogene 5 DKFZp547A023 1p13.2 hypothetical protein DKFZp547A023
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 2161 - 347 - -
2 - 2261 36.2 318 - -
6 - 1185 - 266 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
Nervousbrain   highly
 nerve   highly
Reproductivemale systemtestis  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • conjugated GlycoP , LipoP
    HOMOLOGY
    interspecies ortholog to murine Adora3
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION
    text expressed weakly in the cytoplasm (Cui 2008)
    basic FUNCTION
  • adenosine receptor A3, activating adenylate cyclase
  • involved in signal amplification, controlling ATP gradient sensing and migration of neutrophils
  • protecting the ventricular heart cell against injury during a subsequent exposure to ischemia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in peripheral blood mononuclear cells of rheumatoid arthritis patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS