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FLASH GENE
Symbol ADORA1 contributors: mct/npt/pgu - updated : 28-08-2015
HGNC name adenosine A1 receptor
HGNC id 262
Location 1q32.1      Physical location : 203.096.835 - 203.136.533
Synonym symbol(s) RDC7, A1-AR, A1AR, A1R
DNA
TYPE anonymous DNA segment
STRUCTURE 39.70 kb     4 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D1S399 - D1S202 - [D1S310 - D1S52 - REN - D1S58 - CR2 CR2 ] - D1S54 - D1S245 - qter
Text [ADORA1 ]
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 2937 36.5 326 - 1994 8300646
exon 4,5,6
3 - 2782 - 326 restricted 1994 8300646
exon 3,5,6
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text colocalizing with adenosine deaminase
    basic FUNCTION
  • adenosine receptor A1, with no likely role of promoters polymorphism in bipolar affective disorders inhibiting adenylate cyclase
  • mediate mobilization of calcium in human bronchial smooth muscle cells
  • its activation is needed for normal rebound synchronized slow-wave activity in sleep, suggesting a functional role for synchronized slow-wave homeostasis
  • critical role for adenosine in bone homeostasis via interaction with ADORA1
  • regulates SLC1A2 expression in astrocytes
  • ADORA1 and its downstream signaling regulate SLC1A2 mRNA expression and function
  • might regulate ethanol-sensitive SLC1A2
  • ADORA1 as well as SLC1A2 might regulate ethanol intake
  • ADORA1 and ADORA2B are both involved in differentiation to Treg, but through different mechanisms
  • expression of ADORA1 induced adipocyte differentiation
  • ADORA1, via phospholipase C (PLC)s activation, triggers a nonselective cationic influx occurring through TRPC3 channel
  • Adenosine has a key endogenous neuroprotective role in the brain, predominantly mediated by ADORA1
  • stimulation of ADORA1 enhances the barrier function in vasa vasorum endothelial cells (VVEC) by activation of the Gi/PI3K/Akt pathway and remodeling of actin microfilament
  • may play a role in the development of atherosclerosis, possibly due to its pro-inflammatory and mitogenic properties
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    ADORA1-adenylyl cyclase (AC) pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • adenosine deaminase, required for the high affinity binding of agonist
  • interaction with P2Y(1) receptors that may play an important role in the purinergic signaling cascade in astrocytes, which are involved in cell-to-cell communication and in control of synaptic transmission, particularly during pathological conditions, when large amounts of purines are released
  • caffeine acts via ADORA1 to disrupt embryonic cardiac function
  • important role of adenosine, through ADORA1 in TNFSF11-induced osteoclastogenesis
  • TRPC3 channel activation dependent on ADORA1 activation and playing a predominant role in arrhythmogenesis
  • TRPC3 is involved in conduction disturbances induced by ADORA1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in adipose tissue protects from obesity-related insulin-resistance
    constitutional     --over  
    in frontal cortex from Pick's disease cases
    constitutional       gain of function
    induces angiogenesis
    Susceptibility to bipolar affective disorders
    Variant & Polymorphism other promoter polymorphism not likely involved in bipolar affective disorders
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    osteoarticularboneostéoporosis
    may be a novel pharmacologic target to prevent the bone loss associated with inflammatory diseases and menopause
    ANIMAL & CELL MODELS
  • overexpression of ADORA1 in adipose tissue protects from obesity-related insulin-resistance
  • the splicing of Adora1 and loss of Adora1 expression on alpha-cells may explain the hyperglucagonemia observed in prediabetic NOD mice