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FLASH GENE
Symbol ADIPOR2 contributors: mct - updated : 25-02-2011
HGNC name adiponectin receptor 2
HGNC id 24041
Location 12p13.31      Physical location : 1.800.246 - 1.897.844
Synonym name progestin and adipoQ receptor family member II
Synonym symbol(s) MGC4640, FLJ21432, ACDCR2, PAQR2
DNA
TYPE functioning gene
STRUCTURE 97.59 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 3982 43 386 - 2004 15454091
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   predominantly Homo sapiens
Endocrineadrenal gland   highly
Lymphoid/Immunelymph node   highly
Nervousbraindiencephalonhypothalamus highly
Reproductivefemale systemuteruscervix highly
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell Homo sapiens
Muscularmyocyte Homo sapiens
Reproductivegranulosa cell Homo sapiens
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane domains that are different from classical G-protein-coupled receptors in structure and function
  • a non-conserved region (AAs 181) restricts its cell-surface expression
  • mono polymer homomer , heteromer
    HOMOLOGY
    interspecies ortholog to murine Adipor2
    Homologene
    FAMILY
  • ADIPOR family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • majority of cell-surface ADIPOR2 may be present in the form of hetero-dimers, which are likely to have unique characteristics when compared with ADIPOR1 or ADIPOR2 homo-dimers, respectively
  • basic FUNCTION
  • enhancing the binding of both globular and full-length adiponectin
  • major adiponectin receptors, which mediate the major, if not the entire, part of adiponectin binding and adiponectin actions
  • having a functional role in bone homeostasis
  • may provide an important signal linking fat and body weight to bone density
  • potential role in the regulation of alcohol intake
  • transcriptionally regulated by ER stress-inducible ATF3 in hepatocyte cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by ATF3 (represses adiponectin expression in adipocytes and ADIPOR2 in hepatocytes)
    Other modulated by PPAR and LXR ligands
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in atherosclerotic lesions
    constitutional     --low  
    in obesity playing causal roles, at least in part, in the development of insulin resistance and diabetes
    Susceptibility to atherosclerosis
    Variant & Polymorphism other variants of ADIPOR2 could be a determinant for atherosclerosis independent of insulin resistance status, possibly by affecting ADIPOR2 protein levels
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS