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FLASH GENE
Symbol ADIPOR1 contributors: mct - updated : 25-02-2013
HGNC name adiponectin receptor 1
HGNC id 24040
Location 1q32.1      Physical location : 202.909.962 - 202.927.700
Synonym name progestin and adipoQ receptor family member I
Synonym symbol(s) CGI-45, PAQR1, ACDCR1, TESBP1A, CGI45, FLJ25385, FLJ42464
DNA
TYPE functioning gene
STRUCTURE 17.74 kb     9 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   HRE
text structure
  • promoter activity is repressed by insulin via PI3K and Foxo1
  • presence of a putative insulin-responsive region which is composed of a nuclear inhibitory protein (NIP) binding element
  • ATF3-responsive region in the promoter
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2151 42.6 375 - 2003 12802337
    9 - 2143 - 375 - 2003 12802337
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     liver   highly
     pharynx   highly
    Nervousbraindiencephalonhypothalamus highly
    Reproductivefemale systemuteruscervix highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal predominantly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte Homo sapiens
    Lymphoid/ImmuneB cell Homo sapiens
    Muscularmyocyte Homo sapiens
    Reproductivegranulosa cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal cytoplasmic domain interacted with APPL (adaptor protein containing pleckstrin homology domain, phosphotyrosine-binding domain, and leucine zipper motif
  • seven transmembrane domains that are different from classical G-protein-coupled receptors in structure and function
  • C-terminal extracellular domain interacted with adiponectin
  • mono polymer homomer , heteromer
    HOMOLOGY
    interspecies homolog to murine Adipor1 (96.8pc)
    homolog to rattus Adipor1 (97.6pc)
    Homologene
    FAMILY
  • ADIPOR family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • constitutively expressed on the cell-surface
  • basic FUNCTION
  • enhancing the binding of both globular and full-length adiponectin
  • major adiponectin receptors, which mediate the major, if not the entire, part of adiponectin binding and adiponectin actions
  • critical transcription factor that controls and upregulates the enzymes involved in fatty acid synthesis such as fatty acid synthase (FAS) and acetyl-CoA carboxylase ACC1 in the liver
  • involved with ADIPOQ in the regulation of PGC1A and mitochondria by Ca2+
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TXNDC5 interacts specifically with ADIPOR1, providing evidence that TXNDC5 modulates adiponectin signalling
  • ATF3 interacts directly with its promoter
  • interaction partner of CSNK2B (interaction of ADIPOR1 with the tetrameric complex and CSNK2B is as a key player in adiponectin signaling)
  • cell & other
    REGULATION
    repressed by FOXO1 (implicated in the negative regulation of ADIPOR1 promoter by insulin)
    Other modulated by PPAR and LXR ligands
    negatively regulated by ATF3 in insulin-sensitive cells and insulin secreting cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in atherosclerotic lesions
    constitutional     --low  
    in obesity playing causal roles, at least in part, in the development of insulin resistance and diabetes
    Susceptibility to type 2 diabetes
    Variant & Polymorphism
    Candidate gene
  • decreased level of ADIPOR1 (and ADIPOQ) in obesity may have causal roles in mitochondrial dysfunction and insulin resistance seen in diabetes
  • Marker
    Therapy target
    ANIMAL & CELL MODELS