basic FUNCTION
| adipose tissue-specific plasma protein, involved in insulin sensitizing and having anti-atherosclerotic properties |
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attenuation of the inflammatory response associated with atherogenesis, negative regulator in hematopoiesis and immune system (by suppression of TNF-induced monocyte adhesion to aortic endothelial cells as well as expression of VCAM1), protective factor for the cardiovascular system |
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adipocyte-specific cytokine activating AMPK and directly regulating glucose metabolism and insulin sensitivity |
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pleiotropic mediator of insulin sensitizing with liver and muscle as target organs |
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having unique central effects on energy homeostasis and may be playing a role in the pathogenesis of obesity-related insulin resistance |
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functioning to stimulate the new blood vessel growth by promoting cross-talk between PRKAA2 and Akt signaling within endothelial cells |
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involved in the regulation of cardiac metabolism and function |
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modulates insulin sensitivity and glucose homeostasis |
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acting as a potent regulator of bone resorption observed in diseases associated with cytokine activation |
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may be a more sensitive indicator for latent insulin resistance than IGFBP1 in short SGA (small for gestational age) children |
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having a possible role in the regulation of hepatic fatty acid synthesis (Awazawa 2009) |
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inducing extracellular Ca2+ influx by ADIPOR1, thus regulating PGC1a and mitochondria (Iwabu 2010) |
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adipose-specific glycoprotein hormone having an important role in insulin sensitivity and energy homoeostasis via interaction with two receptors, ADIPOR1 and ADIPOR2 |
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functional member of the pattern-recognition family of defence collagens, with a potentially important role in innate immunity |
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acts through ADIPOR1 to activate MAPK14 and AMPK, resulting in the activations of NFKB on the MMP3 promoter and contribute cartilage destruction during arthritis |
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ADIPOQ, an adipocyte-derived circulating protein, accumulates in the heart, vascular endothelium, and skeletal muscles through an interaction with CDH13, a unique glycosylphosphatidylinositol-anchored cadherin |