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FLASH GENE
Symbol ADI1 contributors: npt/ - updated : 26-04-2006
HGNC name acireductone dioxygenase 1
HGNC id 30576
Location 2p25.3      Physical location : 3.501.690 - 3.523.350
Synonym name
  • submergence induced protein 2
  • membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1
  • 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
  • MT1-MMP cytoplasmic tail-binding protein-1
  • Synonym symbol(s) SIPL, ARD, APL1, HMFT1638, MTCBP-1, FLJ10913, MTCBP1
    EC.number 1.13.-.-
    DNA
    TYPE functioning gene
    STRUCTURE 21.66 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1685 - 179 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveesophagus   moderately
     intestinelarge intestinecolon moderately
     liver   moderately
    Endocrineparathyroid   highly
    Hearing/Equilibriumear   moderately
    Nervousnerve   highly
    Reproductivefemale systemuteruscervix highly
     female systemplacenta  highly
     male systemprostate  moderately
    Respiratorylung   moderately
    Skin/Tegumentskin   moderately
    Urinarykidney   moderately
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to rattus Alp1
    Homologene
    FAMILY
  • cupin superfamily
  • acireductone dioxygenase (ARD) family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • have a role as an invasion suppressor
  • may be involved in methione biosynthesis
  • may have an oxidoreductase activity
  • down-regulating cell migration mediated by MMP14
  • necessary for hepatitis C virus replication in an otherwise non-permissive cell line
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    5-methylthioadenosine (MTA) methionine salvage pathway
    a component
  • complexed with MT1-MMPs (membrane-type 1 matrix metalloproteinases)
  • INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Ni2+ (one ion per monomer)
  • divalent metal cation
  • protein
  • MMP14
  • cell & other
    REGULATION
    Other down-regulated in tumors
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS