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FLASH GENE
Symbol ADH7 contributors: mct - updated : 26-02-2008
HGNC name alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
HGNC id 256
Location 4q23      Physical location : 100.333.418 - 100.356.667
Synonym name
  • gastric alcohol dehydrogenase
  • retinol dehydrogenase
  • Synonym symbol(s) ADH-4
    EC.number 1.1.1.1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text
  • cluster of seven genes spanning approximately 365 kb on chromosome 4q23 (Pochareddy 2010)
  • STRUCTURE 23.11 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure
  • lacking a TATA box and GC boxes upstream of the transcription initiation site
  • MAPPING cloned Y linked N status provisional
    Physical map
    MGC46496 4q22.3-q23 hypothetical protein MGC46496 RAP1GDS1 4q21 RAP1, GTP-GDP dissociation stimulator 1 TM4SF9 4q22.3 transmembrane 4 superfamily member 9 LOC132556 4q23 similar to Transcription factor BTF3 homolog 3 EIF4E 4q21-q25 eukaryotic translation initiation factor 4E METAP1 4q22.3 methionyl aminopeptidase 1 ADH5 4q21-q23 alcohol dehydrogenase 5 (class III), chi polypeptide ADH4 4q21-q24 alcohol dehydrogenase 4 (class II), pi polypeptide LOC359806 4q24 PCNA pseudogene p1PCNA ADH6 4q21-q25 alcohol dehydrogenase 6 (class V) ADH1A 4q21-q23 alcohol dehydrogenase 1A (class I), alpha polypeptide ADH1B 4q21-q23 alcohol dehydrogenase IB (class I), beta polypeptide ADH1C 4q21-q23 alcohol dehydrogenase 1C (class I), gamma polypeptide ADH7 4q23-q24 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide DKFZP434G072 4q23 hypothetical protein DKFZp434G072 MGC27034 4q23 hypothetical protein MGC27034 MTP 4q24 microsomal triglyceride transfer protein (large polypeptide, 88kDa) LOC285556 4q23 hypothetical protein LOC285556 DAPP1 4q25-q27 dual adaptor of phosphotyrosine and 3-phosphoinositides MAP2K1IP1 4q24-q26 mitogen-activated protein kinase kinase 1 interacting protein 1 FLJ14281 4q23 hypothetical protein FLJ14281 H2AFZ 4q24 H2A histone family, member Z LOC256880 4q23 hypothetical LOC256880 LOC115265 EMCN 4q23 endomucin PPP3CA 4q21-q24 protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha)
    regionally located . close to the ADH cluster
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2307 41.35 386 - Xie (1997)
    - - 2120 42.3 394 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  predominantly
     stomach    
    Respiratorylung   highly
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretorydigestive epithelium (mucosa)  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivegastric
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated MetalloP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to murine Adh7
    Homologene
    FAMILY
  • zinc-containing alcohol dehydrogenase family
  • class-IV subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • alcohol dehydrogenase (class IV) sigma polypeptide most active on retinol dehydrogenase, zinc dependent
  • participating in the synthesis of retinoic acid
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism vitamin
    signaling
    synthesis of retinoic acid
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+ (2 ions per subunit)
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to variation of alcohol absorption
    Variant & Polymorphism SNP a recombinational hotspot within intron 7 influencing metabolism of alcohol before its absorption into the blood
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS