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FLASH GENE
Symbol ADH6 contributors: mct - updated : 14-06-2006
HGNC name alcohol dehydrogenase 6 (class V)
HGNC id 255
Location 4q23      Physical location : 100.123.794 - 100.140.403
Synonym name aldehyde reductase
Synonym symbol(s) ADH5
EC.number 1.1.1.1
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text cluster of seven genes spanning approximately 365 kb on chromosome 4q23 (Pochareddy 2010)
STRUCTURE 16.61 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (TATA box)
MAPPING cloned Y linked N status provisional
Physical map
MGC46496 4q22.3-q23 hypothetical protein MGC46496 RAP1GDS1 4q21 RAP1, GTP-GDP dissociation stimulator 1 TM4SF9 4q22.3 transmembrane 4 superfamily member 9 LOC132556 4q23 similar to Transcription factor BTF3 homolog 3 EIF4E 4q21-q25 eukaryotic translation initiation factor 4E METAP1 4q22.3 methionyl aminopeptidase 1 ADH5 4q21-q23 alcohol dehydrogenase 5 (class III), chi polypeptide ADH4 4q21-q24 alcohol dehydrogenase 4 (class II), pi polypeptide LOC359806 4q24 PCNA pseudogene p1PCNA ADH6 4q21-q25 alcohol dehydrogenase 6 (class V) ADH1A 4q21-q23 alcohol dehydrogenase 1A (class I), alpha polypeptide ADH1B 4q21-q23 alcohol dehydrogenase IB (class I), beta polypeptide ADH1C 4q21-q23 alcohol dehydrogenase 1C (class I), gamma polypeptide ADH7 4q23-q24 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide DKFZP434G072 4q23 hypothetical protein DKFZp434G072 MGC27034 4q23 hypothetical protein MGC27034 MTP 4q24 microsomal triglyceride transfer protein (large polypeptide, 88kDa) LOC285556 4q23 hypothetical protein LOC285556 DAPP1 4q25-q27 dual adaptor of phosphotyrosine and 3-phosphoinositides MAP2K1IP1 4q24-q26 mitogen-activated protein kinase kinase 1 interacting protein 1 FLJ14281 4q23 hypothetical protein FLJ14281 H2AFZ 4q24 H2A histone family, member Z LOC256880 4q23 hypothetical LOC256880 LOC115265 EMCN 4q23 endomucin
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1400 39 368 - -
9 - 2803 39.7 375 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
 stomach    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • gluco-corticoid response element at the N terminus
    • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • zinc-containing alcohol dehydrogenase family
  • class-V subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • alcohol dehydrogenase (class V), zinc dependent, metabolizing a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS