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FLASH GENE
Symbol ADH5 contributors: mct/npt - updated : 31-03-2015
HGNC name alcohol dehydrogenase 5 (class III), chi polypeptide
HGNC id 253
Location 4q23      Physical location : 99.992.131 - 100.009.931
Synonym name
  • formaldehyde dehydrogenase
  • alcohol dehydrogenase class 3
  • glutathione-dependent formaldehyde dehydrogenase
  • S-(hydroxymethyl)glutathione dehydrogenase
  • S-nitrosoglutathione reductase
  • glutathione-dependent formaldehyde dehydrogenase
  • Synonym symbol(s) ADH-3, ADHX, FDH, FALDH, GSH-FDH, GSNOR
    EC.number 1.1.1.1, 1.1.1.284
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text cluster of seven genes spanning approximately 365 kb on chromosome 4q23 (Pochareddy 2010)
    STRUCTURE 17.80 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2644 39 374 - Hur (1992)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Reproductivefemale systemuterus  highly
    Respiratoryrespiratory tracttrachea  highly
    Urinarykidney     Rattus norvegicus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated MetalloP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Adh5
    Homologene
    FAMILY
  • alcool dehydrogenase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • alcohol dehydrogenase (class III), chi polypeptide, zinc dependent, catalyzing the oxidation of long-chain primary alcohols and the oxidation of (hydroxymethyl) glutathione
  • alcohol dehydrogenase involved in the regulation of S-nitrosothiols (Sanghani 2009)
  • limits nitric oxide-mediated suppression of NF-kappaB and activation of soluble guanylyl cyclase (Sanghani 2009)
  • NOS3 and ADH5 play an important role in endothelial cell–mediated postnatal angiogenesis and vascular tone
  • protein key to the control of protein S-nitrosylation, is important for the development of lymphocytes
  • likely through regulation of S-nitrosylation and apoptosis, physiologically plays a protective role in the development of the immune system
  • ADH5-signaling contributes to MSC-mediated vasculogenesis
  • involvement of ADH5 and S-nitrosylation in neuromuscular atrophy and neuropathic pain that are associated with pathological states (for example, diabetes and cancer)
  • conserved enzyme for alcohol and aldehyde metabolism in mammals
  • negative regulator of neuronal differentiation
  • counteracts neuronal differentiation of human neural stem cells and that this effect can be reversed by pharmacological inhibition of ADH5
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
    elimination of formaldehyde
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to alcohol dependence
  • to childhood asthma
  • Variant & Polymorphism other
  • increasing the risk of alcohol dependence
  • genetic polymorphisms associated to childhood asthma (Wu 2007)
  • Candidate gene
    Marker
    Therapy target target for the development of therapeutic approaches for treating lung and cardiovascular diseases (Sanghani 2009)
    ANIMAL & CELL MODELS
  • MSCs from Gsnor-deficient mice exhibited attenuated vasculogenesis
  • genetic deletion of Gsnor in mice results in significant decrease in both T and B lymphocytes in the periphery