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FLASH GENE
Symbol ADH1C contributors: mct - updated : 15-09-2010
HGNC name alcohol dehydrogenase 1C (class I), gamma polypeptide
HGNC id 251
Location 4q23      Physical location : 100.257.650 - 100.273.917
Genatlas name see ADH@
Synonym name
  • alcohol dehydrogenase 3 (class I), gamma polypeptide
  • ADH, gamma subunit
  • Synonym symbol(s) ADH3
    EC.number 1.1.1.1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text see ADH@ cluster of seven genes spanning approximately 365 kb on chromosome 4q23 (Pochareddy 2010)
    STRUCTURE 16.27 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1497 39.7 375 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinesmall intestine  highly
     liver   highly
    Endocrineadrenal gland   highly
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • zinc-containing alcohol dehydrogenase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • alcohol dehydrogenase (class I), gamma polypeptide, zinc dependent, playing a major role in ethanol catabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism alcohol , other
    signaling
    a component
  • dimer of identical or nonidentical chains of three types; alpha, beta and gamma
  • INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor, nucleotide,
  • NAD+
  • binds 2 zinc ions per subunit
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to alcoholism in Chinese people (allele 1)
  • to Parkinson disease
  • Variant & Polymorphism other
  • increased risk of alcohol dependence in American Indian population
  • increasing the risk of Parkinson disease
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS