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FLASH GENE
Symbol ADH1B contributors: mct/npt - updated : 30-06-2010
HGNC name alcohol dehydrogenase IB (class I), beta polypeptide
HGNC id 250
Location 4q23      Physical location : 100.227.527 - 100.242.572
Synonym name
  • alcohol dehydrogenase 2 (class I), beta polypeptide
  • identical to FDH
  • ADH, beta subunit
  • Synonym symbol(s) ADH2, DKFZp686C06125
    EC.number 1.1.1.1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text see ADH@ cluster of seven genes spanning approximately 365 kb on chromosome 4q23 (Pochareddy 2010)
    STRUCTURE 15.05 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2689 - 375 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • zinc-binding dehydrogenases
  • conjugated MetalloP
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • alcohol dehydrogenase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • alcohol dehydrogenase (class I), beta polypeptide, zinc dependent, plays a major role in ethanol catabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
    ethanol
    a component
  • homo- and heterodimers of alpha, beta, and gamma subunits
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • putative susceptibility factor for alcoholism
  • to esophageal squamous cell carcinoma (ESCC)
  • to genotoxicity induced by alcohol drinking
  • Variant & Polymorphism SNP , other
  • ADH1B*2 protective against alcoholism in Jewish and in Asian population and susceptibility in caucasians
  • ADHB allele 3 protective among African- Americans
  • SNP rs1229984, alcohol drinking, and smoking are independent risk factors for ESCC (Cui 2009)
  • associations between ADH1B/ALDH2 polymorphisms and genotoxicity in alcohol drinkers (Ishikawa 2007)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS