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FLASH GENE
Symbol ADH1B contributors: mct/npt - updated : 30-06-2010
HGNC name alcohol dehydrogenase IB (class I), beta polypeptide
HGNC id 250
Location 4q23      Physical location : 100.227.527 - 100.242.572
Synonym name
  • alcohol dehydrogenase 2 (class I), beta polypeptide
  • identical to FDH
  • ADH, beta subunit
  • Synonym symbol(s) ADH2, DKFZp686C06125
    EC.number 1.1.1.1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text see ADH@ cluster of seven genes spanning approximately 365 kb on chromosome 4q23 (Pochareddy 2010)
    STRUCTURE 15.05 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    MGC46496 4q22.3-q23 hypothetical protein MGC46496 RAP1GDS1 4q21 RAP1, GTP-GDP dissociation stimulator 1 TM4SF9 4q22.3 transmembrane 4 superfamily member 9 LOC132556 4q23 similar to Transcription factor BTF3 homolog 3 EIF4E 4q21-q25 eukaryotic translation initiation factor 4E METAP1 4q22.3 methionyl aminopeptidase 1 ADH5 4q21-q23 alcohol dehydrogenase 5 (class III), chi polypeptide ADH4 4q21-q24 alcohol dehydrogenase 4 (class II), pi polypeptide LOC359806 4q24 PCNA pseudogene p1PCNA ADH6 4q21-q25 alcohol dehydrogenase 6 (class V) ADH1A 4q21-q23 alcohol dehydrogenase 1A (class I), alpha polypeptide ADH1B 4q21-q23 alcohol dehydrogenase IB (class I), beta polypeptide ADH1C 4q21-q23 alcohol dehydrogenase 1C (class I), gamma polypeptide ADH7 4q23-q24 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide DKFZP434G072 4q23 hypothetical protein DKFZp434G072 MGC27034 4q23 hypothetical protein MGC27034 MTP 4q24 microsomal triglyceride transfer protein (large polypeptide, 88kDa) LOC285556 4q23 hypothetical protein LOC285556 DAPP1 4q25-q27 dual adaptor of phosphotyrosine and 3-phosphoinositides MAP2K1IP1 4q24-q26 mitogen-activated protein kinase kinase 1 interacting protein 1 FLJ14281 4q23 hypothetical protein FLJ14281 H2AFZ 4q24 H2A histone family, member Z LOC256880 4q23 hypothetical LOC256880 LOC115265 EMCN 4q23 endomucin
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2689 - 375 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • zinc-binding dehydrogenases
  • conjugated MetalloP
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • alcohol dehydrogenase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • alcohol dehydrogenase (class I), beta polypeptide, zinc dependent, plays a major role in ethanol catabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
    ethanol
    a component
  • homo- and heterodimers of alpha, beta, and gamma subunits
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • putative susceptibility factor for alcoholism
  • to esophageal squamous cell carcinoma (ESCC)
  • to genotoxicity induced by alcohol drinking
  • Variant & Polymorphism SNP , other
  • ADH1B*2 protective against alcoholism in Jewish and in Asian population and susceptibility in caucasians
  • ADHB allele 3 protective among African- Americans
  • SNP rs1229984, alcohol drinking, and smoking are independent risk factors for ESCC (Cui 2009)
  • associations between ADH1B/ALDH2 polymorphisms and genotoxicity in alcohol drinkers (Ishikawa 2007)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS