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FLASH GENE
Symbol ADCYAP1R1 contributors: mct - updated : 06-01-2021
HGNC name adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
HGNC id 242
Location 7p14.3      Physical location : 31.092.141 - 31.146.311
Synonym name
  • pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop
  • adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
  • (PACAP) type 1 receptor (PAC1R)
  • Synonym symbol(s) PACAPR, PAC1R, PACAPR1
    EC.number 4.6.1.1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 59.17 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - - - 525 - 2018 28926110
    - splicing - - - - 2018 28926110
    cytoplasmic insertion between TM5 and TM6, activating adenylate cyclase and phospholipase C
    - - - - - - 2018 28926110
    cytoplasmic insertion between TM5 and TM6, activating adenylate cyclase and phospholipase C
    - splicing - - - - 2018 28926110
    cytoplasmic insertion between TM5 and TM6, activating adenylate cyclase and phospholipase C
    - splicing - - - - 2018 28926110
    cytoplasmic insertion between TM5 and TM6, activating phospholipase C
    - - - - - - 2018 28926110
    cytoplasmic insertion between TM5 and TM6, activating phospholipase C
    17 - 6723 - 496 - 2018 28926110
    17 - 6720 - 495 - 2018 28926110
    16 - 6639 - 468 - 2018 28926110
    14 - 6576 - 447 - 2018 28926110
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary   
    Nervousbraindiencephalonamygdala highly Homo sapiens
     nerve    
    Respiratoryrespiratory tracttrachea   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
  • with an insertion between TM5 and TM6 in variants
  • HOMOLOGY
    interspecies homolog to murine Adcyap1r1
    Homologene
    FAMILY secretin family,coupling with Gs alpha protein and activating adenylate cyclase
    CATEGORY enzyme , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in the physiological control of insulin release
  • four spliced variants activating phospholipase C and one, the variant (PACAPR-TM4), activating L-type Ca++ channels
  • has neurodevelopmental functions in the human cerebellum
  • VIPR2 and/or ADCYAPR1 receptor activation is involved in cutaneous active vasodilation in humans
  • play a critical role in biological processes that mediate stress response and have been implicated in psychological outcome following trauma
  • importance of ADCYAP1R1 endosomal signaling as a key mechanism regulating cellular function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with IGF1R (ADCYAP1R1 transactivation is essential for IGF1 receptor signaling and antiapoptotic activity in neurons)
  • action of GNRH1 in the regulation of gonadotropin subunit expression is enhanced by the presence of ADCYAP1R1
  • ADCYAP1/ADCYAP1R1 internalization and recruitment of endosomal signaling regulate cardiac neuron excitability
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in macrophages is a common mechanism in response to acute and chronic pro-inflammatory stimuli
    Susceptibility
  • to Cluster Headache (CH)
  • to Posttraumatic stress disorder (PTSD)
  • to severity of social deficits and functional amygdala connectivity in autism spectrum disorder
  • Variant & Polymorphism
  • association of CH with a common variant of the PACAP receptor gene (ADCYAP1R1)
  • sex-dependent association between ADCYAP1R1 and Posttraumatic stress disorder (PTSD)
  • ADCYAP1R1 genotype is linked to severity of social deficits and functional amygdala connectivity in ASD
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS