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FLASH GENE
Symbol ADCY8 contributors: mct - updated : 27-09-2010
HGNC name adenylate cyclase 8 (brain)
HGNC id 239
Location 8q24.22      Physical location : 131.792.547 - 132.052.835
Synonym name
  • Ca(2+)/calmodulin-activated adenylyl cyclase
  • adenylate cyclase type VIII
    • Synonym symbol(s) AC8, BAC1, ADCY3, HBAC1
    EC.number 4.6.1.1
    DNA
    TYPE functioning gene
    STRUCTURE 262.13 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 4145 140.1 1251 - PMID: 8076676
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text abundant during development, with diffuse and increasing expression in the hippocampus
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 1-5-8-14 motif at the N terminus, and N-terminal CaM binding domain that has a role in recruiting CALM1 and this recruitment is essential to permit stimulation by Ca2+
  • two homologous domains
  • first 77 AAs contain a helical calmodulin binding domain, located between residues 34 and 51
  • two CaM-binding domains,
  • an IQ-like motif (IQlm) at the C terminus
    • HOMOLOGY
    interspecies ortholog to murine Adcy8
    Homologene
    FAMILY
  • adenylyl cyclase class-4/guanylil cyclase family
    • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • membrane-bound, calcium inhibitable adenyl cyclase involved in learning, memory, drug dependance
  • with ADCY1, are the only cyclases stimulated by calcium and calmodulin, making them uniquely poised to regulate neuronal development and neuronal processes such as learning and memory
  • plays a particularly important role in rapidly resetting the balance of active to silent synapses after adaptation to strong activity
  • Ca2+-stimulable adenylate cyclase, interacting with an AKAP and role for AKAP5 in the attenuation of Ca2+-dependent ADCY8 activity
  • essential component of a signaling pathway that opposes repellent signaling, and helps regulate retinal sensitivity to midline guidance cues
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with AKAP5 mediates inhibition of Ca2+-dependent cAMP production
  • AKAP5 directly bind to adenylyl cyclase type 8 (ADCY8) and regulate its responsiveness to store-operated Ca2+ entry (SOCE)
    • cell & other
    REGULATION
    activated by Ca(2+)/calmodulin (CaM), and having discrete neuronal functions
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS