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FLASH GENE
Symbol ADCY8 contributors: mct - updated : 27-09-2010
HGNC name adenylate cyclase 8 (brain)
HGNC id 239
Location 8q24.22      Physical location : 131.792.547 - 132.052.835
Synonym name
  • Ca(2+)/calmodulin-activated adenylyl cyclase
  • adenylate cyclase type VIII
  • Synonym symbol(s) AC8, BAC1, ADCY3, HBAC1
    EC.number 4.6.1.1
    DNA
    TYPE functioning gene
    STRUCTURE 262.13 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC389685 8 LOC389685 NSE2 8q24.13 breast cancer membrane protein 101 POU5F1P1 8q13.2-q13.3 POU domain, class 5, transcription factor 1 pseudogene 1 MYC 8q24.12-q24.13 v-myc myelocytomatosis viral oncogene homolog (avian) PVT1 8q24 Pvt1 oncogene homolog, MYC activator (mouse) LOC389686 8 LOC389686 MGC27434 8q24.21 hypothetical protein MGC27434 LOC389687 8 LOC389687 MLZE 8q24.1-q24.2 melanoma-derived leucine zipper, extra-nuclear factor BM-009 8q24.21 hypothetical protein BM-009 HSPC054 8q24.21 HSPC054 protein ADCY8 8q24 adenylate cyclase 8 (brain) KIAA0143 8q24.22 KIAA0143 protein LOC137202 HHLA1 8q24 HERV-H LTR-associating 1 KCNQ3 8q24 potassium voltage-gated channel, KQT-like subfamily, member 3 TSLRP 8q24.22 testis specific leucine rich repeat protein FLJ33069 8q24.22 hypothetical protein FLJ33069 CGI-72 8q24.22 CGI-72 protein TG 8q24.3 thyroglobulin SLA 8q23.3-q24.3 Src-like-adaptor WISP1 8q24.1-q24.3 WNT1 inducible signaling pathway protein 1 NDRG1 8q24.3 N-myc downstream regulated gene 1 LOC392271 8 similar to 60S ribosomal protein L32 FAM10A6 8q24.22 family with sequence similarity 10, member A6 LOC389688 8 LOC389688 SIAT4A 8q24.22 sialyltransferase 4A (beta-galactoside alpha-2,3-sialyltransferase) ZNF406 8q24.22 zinc finger protein 406 LOC286094 8q24.23 hypothetical protein LOC286094 KHDRBS3 8q22-q24.2 KH domain containing, RNA binding, signal transduction associated 3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 4145 140.1 1251 - PMID: 8076676
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text abundant during development, with diffuse and increasing expression in the hippocampus
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 1-5-8-14 motif at the N terminus, and N-terminal CaM binding domain that has a role in recruiting CALM1 and this recruitment is essential to permit stimulation by Ca2+
  • two homologous domains
  • first 77 AAs contain a helical calmodulin binding domain, located between residues 34 and 51
  • two CaM-binding domains,
  • an IQ-like motif (IQlm) at the C terminus
  • HOMOLOGY
    interspecies ortholog to murine Adcy8
    Homologene
    FAMILY
  • adenylyl cyclase class-4/guanylil cyclase family
  • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • membrane-bound, calcium inhibitable adenyl cyclase involved in learning, memory, drug dependance
  • with ADCY1, are the only cyclases stimulated by calcium and calmodulin, making them uniquely poised to regulate neuronal development and neuronal processes such as learning and memory
  • plays a particularly important role in rapidly resetting the balance of active to silent synapses after adaptation to strong activity
  • Ca2+-stimulable adenylate cyclase, interacting with an AKAP and role for AKAP5 in the attenuation of Ca2+-dependent ADCY8 activity
  • essential component of a signaling pathway that opposes repellent signaling, and helps regulate retinal sensitivity to midline guidance cues
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with AKAP5 mediates inhibition of Ca2+-dependent cAMP production
  • AKAP5 directly bind to adenylyl cyclase type 8 (ADCY8) and regulate its responsiveness to store-operated Ca2+ entry (SOCE)
  • cell & other
    REGULATION
    activated by Ca(2+)/calmodulin (CaM), and having discrete neuronal functions
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS