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FLASH GENE
Symbol ADCY10 contributors: npt - updated : 14-02-2006
HGNC name adenylate cyclase 10 (soluble)
HGNC id 21285
Corresponding disease
AHCU absorptive hypercalciuria
Location 1q23.3-q24      Physical location : 167.778.624 - 167.883.453
Synonym name
  • AH-related protein
  • testicular soluble adenylyl cyclase
  • germ cell soluble adenylyl cyclase
  • hypercalciuria, absorptive, 2
  • 3', 5'-cyclic AMP synthetase
    • Synonym symbol(s) HCA2, TSAC, RP1-313L4.2, SAC, Sacy, SACI
    EC.number 4.6.1.1
    DNA
    TYPE functioning gene
    STRUCTURE 104.00 kb     33 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 5061 - 1610 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivemale systemtestis  predominantly
    Respiratoryrespiratory tractlarynx   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Sacy
    Homologene
    FAMILY
    CATEGORY motor/contractile , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • functioning as a general bicarbonate sensor throughout the body
  • may be playing an important role in the generation of cAMP in spermatozoa, implying possible role in sperm maturation through the epididymis, capacitation, hypermotility, and/or the acrosome reaction
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AHCU
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS