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FLASH GENE
Symbol ADCY1 contributors: mct - updated : 27-09-2010
HGNC name adenylate cyclase 1 (brain)
HGNC id 232
Location 7p13      Physical location : 45.614.124 - 45.762.712
Synonym name
  • ATP pyrophosphate lyase
  • 3',5'-cyclic AMP synthetase
  • Ca(2+)/calmodulin-activated adenylyl cyclase
  • Synonym symbol(s) AC1, BACF1, CYA1
    EC.number 4.6.1.1
    DNA
    TYPE functioning gene
    STRUCTURE 148.59 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    DDX56 7p13 DEAD (Asp-Glu-Ala-Asp) box polypeptide 56 HNLF 7p13 putative NFkB activating protein HNLF LOC392665 7 similar to myosin IG OGDH 7p14-p13 oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) C7orf22 7p13 chromosome 7 open reading frame 22 LOC392666 7 similar to KIAA0363 CPR2 7p14-p13 similar to KIAA0363 DKFZp761I2123 7p13 hypothetical protein DKFZp761I2123 RAMP3 7p13-p12 receptor (calcitonin) activity modifying protein 3 PPIA 7p13-p11.2 peptidylprolyl isomerase A (cyclophilin A) H2AV 7p13 H2A histone family, member V PURB 7p13 purine-rich element binding protein B MRPS23P1 7p13 mitochondrial ribosomal protein S23 pseudogene 1 MYO1G 7p13-p11.2 myosin IG C7orf22 7p13 chromosome 7 open reading frame 22 KIAA0363 7p14-p11.2 chromosome 7 open reading frame 22 CPR2 7p14-p13 chromosome 7 open reading frame 22 RAMP3 7p13-p12 receptor (calcitonin) activity modifying protein 3 ADCY1 7p13-p12 adenylate cyclase 1 (brain) LOC392667 7 similar to cell division cycle 10 homolog LOC339494 7 hypothetical LOC339494 LOC392668 7 similar to hypothetical protein LOC349114 LOC392894 7 similar to capicua homolog IGFBP1 7p13-p12 insulin-like growth factor binding protein 1 IGFBP3 7p13-p12 insulin-like growth factor binding protein 3 ADCY1 7p13-p12 adenylate cyclase 1 (brain) LOC392895 7 similar to Tetratricopeptide repeat protein 4 (My044 protein) LOC389487 7 similar to cell division cycle 10 homolog LOC389488 7 similar to hypothetical protein LOC349114 LOC392024 7 similar to capicua homolog IGFBP1 7p13-p12 insulin-like growth factor binding protein 1 IGFBP3 7p13-p12 insulin-like growth factor binding protein 3 LOC222052 7p13 similar to Tetratricopeptide repeat protein 4 (My044 protein) CNTNAP2 7q35.1-q35.2 contactin associated protein-like 2 PRO1866
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 12499 123.31 1119 - PMID: 19029295
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Nervousbrainhindbraincerebellum highly
     brainlimbic systemhippocampus highly
     braindiencephalonthalamus highly
    Visualeye   predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular   moderately
    Nervousautonomous   
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two guanylate cyclase domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Adcy 1 (92.4pc)
    ortholog to murine Adcy1 (92.7pc)
    Homologene
    FAMILY
  • adenylyl cyclase class-4/guanylyl cyclase family
  • CATEGORY enzyme , regulatory , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in regulatory processes in the central nervous system
  • only required for the maturation of the retinal axon terminals whereas ADCY5 and ADCY8 are not needed
  • with ADCY8, are the only cyclases stimulated by calcium and calmodulin, making them uniquely poised to regulate neuronal development and neuronal processes such as learning and memory
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism purine/pyrimidine
    signaling signal transduction
    cAMP biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Mg2+ (2 ions per subunit)
  • protein
  • direct anchoring of both PRKACA and ADCY1 to TRPV1 by AKAP5 facilitates the response to inflammatory mediators and may be critical in the pathogenesis of thermal hyperalgesia
  • anchoring of not only PRKACA but also ADCY1 by AKAP5 is important for regulation of postsynaptic functions and specifically AMPA receptor activity
  • cell & other
    REGULATION
    activated by Ca(2+)/calmodulin (CaM), and having discrete neuronal functions
    inhibited by the G protein beta and gamma subunit complex
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS