Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ADC contributors: mct - updated : 27-05-2011
HGNC name arginine decarboxylase
HGNC id 29957
Location 1p35.1      Physical location : 33.546.713 - 33.585.994
Synonym name
  • ornithine decarboxylase-like protein
  • ODC-paralogue
  • antizyme inhibitor 2
  • Synonym symbol(s) ODC-p, ODCL, ODC1L, KIAA1945, ARGDC, AZIN2
    EC.number 4.1.1.17, 4.1.1.19
    DNA
    TYPE functioning gene
    STRUCTURE 39.28 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2210 49.85 460 - 2001 11587527
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbrainmedulla oblongata   Homo sapiens
    Reproductivemale systemtestis    Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • pyridoxal-dependent decarboxylase, pyridoxal binding domain
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to rattus Odc1
    ortholog to murine Odc1
    intraspecies homolog to AZIN1 (highly)
    Homologene
    FAMILY
  • Orn/Lys/Arg decarboxylase class-II family
  • antizyme inhibitor family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    text
  • located in the ER-Golgi intermediate compartment (ERGIC) and in the cis-Golgi network
  • basic FUNCTION
  • playing a role in terminal differentiation rather than cell proliferation
  • affects polyamine homeostasis not only by increasing ornithine decarboxylase activity but also by stimulating polyamine uptake, through negating the inhibitory effect of the antizymes
  • AZIN1 and ADC, that bind to OAZs and negate their effects on polyamine metabolism
  • labile protein that is degraded by the proteasome by a ubiquitin-dependent mechanism
  • AZIN1 and ADC are proteins that activate ornithine decarboxylase (ODC1), the key enzyme of polyamine biosynthesis
  • acts as a regulator of vesicle trafficking
  • regulates the transport of secretory vesicles by locally activating ODC1 and polyamine biosynthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • pyridoxal phosphate
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS