basic FUNCTION
| playing a role in terminal differentiation rather than cell proliferation |
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affects polyamine homeostasis not only by increasing ornithine decarboxylase activity but also by stimulating polyamine uptake, through negating the inhibitory effect of the antizymes |
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AZIN1 and ADC, that bind to OAZs and negate their effects on polyamine metabolism |
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labile protein that is degraded by the proteasome by a ubiquitin-dependent mechanism |
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AZIN1 and ADC are proteins that activate ornithine decarboxylase (ODC1), the key enzyme of polyamine biosynthesis |
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acts as a regulator of vesicle trafficking |
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regulates the transport of secretory vesicles by locally activating ODC1 and polyamine biosynthesis |