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FLASH GENE
Symbol ADAT3 contributors: mct/npt - updated : 26-06-2008
HGNC name adenosine deaminase, tRNA-specific 3, TAD3 homolog (S. cerevisiae)
HGNC id 25151
Location 19p13.3      Physical location : 1.905.416 - 1.913.443
Synonym name
  • tRNA-specific adenosine deaminase 3 homolog (S. cerevisiae)
  • tRNA-specific adenosine-34 deaminase subunit ADAT3
  • adenosine deaminases acting on tRNA 3
  • Synonym symbol(s) TAD3, FWP005, MST121, MSTP121, S863-5, TAD3P
    DNA
    TYPE functioning gene
    STRUCTURE 8.00 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1597 38 351 - Schaub (2002)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
    Reproductivemale systemprostate  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    interspecies homolog to S. Cerevisiae Tad3
    Homologene
    FAMILY
  • cytidine and deoxycytidylate deaminase family
  • ADAT3 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • involved in inosine formation in tRNAs
  • with ADAT2 function as a heterodimer which catalyses inosine formation at the wobble position (position 34) in eukaryotic tRNAs
  • playing an essential role for cell viability, illustrating the biological importance of A-to-I editing at the wobble position of tRNA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS