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FLASH GENE
Symbol ADAT1 contributors: mct - updated : 12-09-2023
HGNC name adenosine deaminase, tRNA-specific 1
HGNC id 228
Location 16q23.1      Physical location : 75.632.246 - 75.657.221
Synonym name tRNA-specific adenosine-37 deaminase
Synonym symbol(s) HADAT1
EC.number 3.5.4.34
DNA
TYPE functioning gene
STRUCTURE 26.43 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 4984 55.2 502 - 1999 10430867
9 - 4738 - 420 - 1999 10430867
9 - 4796 - 271 - 1999 10430867
11 - 5042 - 353 - 1999 10430867
11 - 5775 - 353 - 1999 10430867
7 - 5456 - 333 - 1999 10430867
8 - 5511 - 420 - 1999 10430867
10 - 5757 - 520 - 1999 10430867
9 - 5702 - 415 - 1999 10430867
8 - 5569 - 271 - 1999 10430867
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   moderately
Nervousbrain   moderately
Reproductivefemale systemuterus   
Respiratorylung   moderately
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Adat1
homolog to S. CEREVISIAE Tad1
Homologene
FAMILY
  • ADAR (adenosine deaminase acting on RNA) family, of RNA editing enzymes
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • involved in a specific deamination of the adenosine 37 of eukaryotic tRNA-Ala to inosine
  • specifically converts A37 in the anticodon loop of human tRNA(Ala) to inosine via a hydrolytic deamination mechanism
  • CELLULAR PROCESS protein, editing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS