basic FUNCTION
| double-stranded RNA adenosine editing deaminase |
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involved in site-selective editing of neural glutamate and serotonin receptors and in generation of biased hypermutations of viral DNA |
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required for embryonic erythropoiesis in mice |
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plays an essential role in adult hematopoiesis through its RNA editing activity in hematopoietic stem cells |
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novel regulatory role for ADAR activation under inflammatory stress to both promote muscle protein synthesis pathways and limit atrophy pathways |
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ADAR functioned to promote survival of numerous tissues by editing one or more double-stranded RNAs required for protection against stress-induced apoptosis |
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dysfunction of ADAR might be an important event in leukemias |
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ADARB1 and ADAR have evolved highly conserved, distinct functions |
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functions as a suppressor of dsRNA-mediated antiviral responses including activation of EIF2AK2 and interferon regulatory factor 3 |
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possible role for ADAR as a suppressor of type I interferon signaling |
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may limit the cytoplasmic accumulation of the dsRNA generated from genomic repetitive elements |
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having potentially a role in the metabolism of retroelements and a major contribution of ADAR to evolutionary fitness may be to regulate the accumulation of dsRNA generated from basally transcribed repetitive sequences within the genome |
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catalyze the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) and thereby potentially alter the information content and structure of cellular RNAs |
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regulates osteoblast differentiation by, at least in part, modulation of osterix expression, which is essential for bone formation |
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promotes malignant progenitor reprogramming in chronic myeloid leukemia |
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plays a major role in splicing regulation |
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ADAR coordinates with ADARB1 to regulate editing and stability of Cat2 transcribed nuclear RNA (Ctn RNA) |