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FLASH GENE
Symbol ADAP1 contributors: mct - updated : 26-11-2014
HGNC name ArfGAP with dual PH domains 1
HGNC id 16486
Location 7p22.3      Physical location : 937.537 - 994.289
Synonym name
  • putative MAPK-activating protein PM25
  • centaurin alpha 1
  • putative MAPK-activating protein PM25
  • Synonym symbol(s) GCS1L, p42IP4, CENTA1
    DNA
    TYPE functioning gene
    STRUCTURE 57.51 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text eight alternative transcripts encoding seven proteins
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2195 - 385 - 1999 10448098
    11 - 2368 - 374 - 1999 10448098
    11 - 2135 - 302 - 1999 10448098
    10 - 2110 - 302 - 1999 10448098
    9 - 1963 - 279 - 1999 10448098
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Nervousbrain   specific Homo sapiens
     nerve   highly
     nervecranial nerve  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal ArfGAP domain
  • two PH domains, first PH domain specifically binds to PIP3, while the second binds to both PIP3 and phosphatidylinositol 3,4-biphosphate (PI(3,4)P(2))
  • a putative ADP ribosylation factor GTPase-activating protein domain
  • ankyrin repeats
  • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies ortholog to yeast ADP-ribosylation factor,GTPase activating protein
    intraspecies paralog to GSC1L2 (CENTA2)
    Homologene
    FAMILY
  • AZAP family of phosphoinositide-regulated Arf GAPs
  • ADAP subfamily
  • CATEGORY protooncogene , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • endogenous centaurin alpha1 protein is localized in the synaptosome fraction, with peak expression in early postnatal development
  • cytosolic protein recruited to plasma membrane following stimulation with either NGF or EGF, in a PI-3 kinase dependent manner
  • localized in mitochondria
  • basic FUNCTION
  • ARF GTPase-activating protein, controlling the return of ARF to the inactive GDB-bound shots
  • functioning as mediator of cellular transformation
  • contributes to ERK activation in growth factor signaling, linking the PI3K pathway to the ERK mitogen-activated protein kinase pathway through its ability to interact with PIP3
  • functions through GAP-dependent Arf regulation of dendritic branching and spines that underlie normal dendritic differentiation and development
  • may be a component of the neuronal PI 3-kinase cascade that leads to regulation of the neuronal actin cytoskeleton
  • is involved in the regulation of Ca(2+) transport in mitochondria
  • functional roles of ADAP1 in neuronal differentiation and neurodegeneration
  • can function as a scaffolding protein in several signal transduction pathways
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling signal transduction
  • CENTA1-RAS-ELK1 signaling pathway acts on mitochondria to regulate dendritic spine density and synaptic plasticity in response to APP in hippocampal neurons
  • a component
  • KIF13B and ADAP1 form heterotetramers that can bind four phosphoinositide molecules in the vesicle and transport it along the microtubule
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ADAP1 and RANBP9 were shown to be involved in dendritic differentiation and RANBP9 could potentially act as a modulator together with ADAP1 in synaptic plasticity
  • KIF13B interacts with ADAP1 through its forkhead-associated (FHA) domain
  • ADAP1 interacts with the metalloendopeptidase nardilysin (NRD1) and is localized in neuritic plaques in Alzheimer disease (AD) brains
  • cell & other
  • targeted by phosphatidyl inositol (3,4,3) triphosphate
  • REGULATION
    activated by EGF,NGF
    Other regulated by AP-1 in oncogenic activity
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS