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FLASH GENE
Symbol ADAMTSL3 contributors: mct - updated : 07-11-2009
HGNC name ADAMTS-like 3
HGNC id 14633
Location 15q25.1      Physical location : 84.322.837 - 84.708.591
Synonym name
  • protein with immunoglobulin and thrombospondin domain
  • punctin-2
  • a disintegrin-like and metalloprotease domain with thrombospondin type I motifs-like 3
    • Synonym symbol(s) KIAA1233, MGC150716, MGC150717
    DNA
    TYPE functioning gene
    STRUCTURE 385.76 kb     30 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    30 - 7336 186 1691 - 2007 17597111
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinelarge intestinecolon   Homo sapiens
     liver   highly Homo sapiens
    Hearing/Equilibriumearouter   
    Reproductivefemale systembreast    Homo sapiens
    Skin/Tegumentskin     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveepithelial cell Homo sapiens
    Endocrineislet cell (alpha,beta...) Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • immunoglobulin and thrombospondin domain
  • one disintegrin-like domain
  • one plac domain
  • 13 thrombospondin type 1 repeats (TSRs), arranged in two arrays separated by a region containing three immunoglobulin-like repeats
  • a cysteine-rich domain and a cysteine-free spacer domain in the precise order in which they occur in the ADAMTS proteases
    • HOMOLOGY
    interspecies homolog to murine Adamtsl3
    Homologene
    FAMILY
  • ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may be having important functions in the extracellular matrix
  • might play a role in cell-matrix interactions or in assembly of specific extracellular matrices
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associate with ECM molecules through its TSR domains after secretion
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in colorectal carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS