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FLASH GENE
Symbol ADAMTS8 contributors: npt/ - updated : 10-04-2006
HGNC name ADAM metallopeptidase with thrombospondin type 1 motif, 8
HGNC id 224
Location 11q25      Physical location : 130.274.819 - 130.298.539
Synonym name
  • angiostatic and likely tumor suppressor
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8
    • Synonym symbol(s) METH2, FLJ41712, ADAM-TS8, METH-8
    EC.number 3.4.24.-
    DNA
    TYPE functioning gene
    STRUCTURE 23.72 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 3679 96.3 889 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary   
     male systemprostate   
    Respiratorylung    
    Visualeyeretina   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a prodomain
  • a Zn-binding site containing a disintegrin-like domain
  • two C terminal TS1 motifs
    • conjugated MetalloP
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    text extracellular matrix
    basic FUNCTION
  • implicated in the mechanism of neovascularisation
  • may be involved in cell migration in the retina
    • CELLULAR PROCESS cell life, proliferation/growth
    protein, degradation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text disruption of angiogenesis negative control of proliferation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS