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FLASH GENE
Symbol ADAMTS3 contributors: npt/ - updated : 14-11-2006
HGNC name ADAM metallopeptidase with thrombospondin type 1 motif, 3
HGNC id 219
Location 4q21      Physical location : 73.146.686 - 73.434.516
Synonym name
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 3
  • procollagen II N-proteinase 3
  • procollagen II amino propeptide-processing enzyme
    • Synonym symbol(s) KIAA0366, ADAMTS-4, ADAM-TS3
    EC.number 3.4.24.-
    DNA
    TYPE functioning gene
    STRUCTURE 288.00 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 5821 135.6 1205 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Visualeyeretina   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal sequence
  • a propeptide domain
  • a reprolysin-type catalytic domain
  • a disintegrin-like domain
  • a thrombospondin type 1 (TSP1) module
  • a cysteine rich domain
  • a spacer domain without cysteine residues
  • three terminal TSP-like modules
    • conjugated MetalloP
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • a disintegrin-like and metalloprotease activity
  • cell surface adhesion protein
  • pro-collagen N-propeptidase activity
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS