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FLASH GENE

Symbol

ADAMTS14

contributors: npt/ - updated : 06-02-2006

HGNC name	ADAM metallopeptidase with thrombospondin type 1 motif, 14
HGNC id	14899

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	10q21.3      Physical location : 72.432.558 - 72.522.193
Synonym name	a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 14
	metalloprotease-disintegrin protease
Synonym symbol(s)	ADAM-TS14, FLJ32820
EC.number	3.4.24.-

DNA

TYPE	functioning gene
STRUCTURE	89.64 kb     22 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	using two different promoters

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - splicing initiation site 3721 133.9 1223 - Colige variant 2 - splicing initiation site 3730 134.2 1226 - Colige

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       lowly Respiratory lung       lowly Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	lung and kidney, placenta (lowly)

PROTEIN

PHYSICAL PROPERTIES		Amphiphilic
STRUCTURE

motifs/domains	a propeptide region
	a metalloproteinase domain
	a disintegrin-like domain
	a cysteine-rich domain
	a thrombospondin type 1 (TS) motif

conjugated

MetalloP

HOMOLOGY

interspecies	homolog to Drosophila kst
	homolog to murine Adamts 14
	homolog to C.elegans sma-1

intraspecies	homolog to ADAMTS3
	homolog to ADAMTS2

Homologene

FAMILY

ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family

CATEGORY

adhesion , enzyme

SUBCELLULAR LOCALIZATION	extracellular
text	associated with the extracellular matrix

basic FUNCTION	having aminoprocollagen activity
	active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS