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FLASH GENE
Symbol ADAMTS12 contributors: mct - updated : 25-09-2018
HGNC name ADAM metallopeptidase with thrombospondin type 1 motif, 12
HGNC id 14605
Location 5p13.3      Physical location : 33.527.286 - 33.892.124
Synonym name
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12
  • Synonym symbol(s) AT12, ADAM-TS12, PRO4389
    EC.number 3.4.24.-
    DNA
    TYPE functioning gene
    STRUCTURE 368.66 kb     24 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 - 8791 150 1594 - 2012 23019333
    22 - 8536 - 1509 - 2012 23019333
    3 - 1177 - 232 - 2012 23019333
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   lowly
    Reproductivemale systemprostate  moderately
    Respiratorylung   moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticneutrophil Homo sapiens
    not specificchondrocyte Homo sapiens
    cell lineage
    cell lines gastric tumor cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text pulmonary cells in development
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one propeptide region
  • one metalloproteinase domain
  • one disintegrin-like domain
  • eight thrombospondin type 1 (TSP1) motif
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion
  • ADAMTS12 confers tumour-protective functions upon cells that produce this proteolytic enzyme
  • displays antiangiogenic properties and protect the host toward tumor progression
  • ADAMTS12, independent of its proteolytic activity, plays a specific, non-redundant role in trophoblast invasion
  • ADAMTS7 and ADAMTS12 appear to be potent negative regulators of endplate cartilage development
  • is a degradative enzyme that interacts with the degradable fragments of cartilage oligomeric matrix protein, which is a prominent non-collagenous matrix component in articular cartilage
  • ADAMTS12 is implicated in the inflammatory response by modulating normal neutrophil apoptosis
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • ADAMTS12, a downstream molecule of PTHLH signaling, is a novel regulator of chondrogenesis
  • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • the four C-terminal TSP-1-like repeats of ADAMTS12 are shown to be necessary and sufficient for its interaction with COMP
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in the maternal and cord blood were lower in the preeclampsia group than in the control group
    Susceptibility to rheumatoid arthritis (RA)
    Variant & Polymorphism SNP
  • rs10461703 significantly associated to RA
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Adamts12-deficient mice are more susceptible to cancer development, displaying increased angiogenesis and tumor invasion