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FLASH GENE
Symbol ADAMDEC1 contributors: mct - updated : 24-09-2010
HGNC name ADAM-like, decysin 1
HGNC id 16299
Location 8p21.2      Physical location : 24.241.797 - 24.263.526
Synonym name
  • decysin
  • disintegrin protease
  • ADAM-like protein decysin 1
  • Synonym symbol(s) M12.219, DECYSIN
    EC.number 3.4.24.-
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text clustered with ADAM7 and ADAM28
    STRUCTURE 21.73 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC389640 8 LOC389640 TNFRSF10C 8p21 tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain TNFRSF10D 8p21 tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain TNFRSF10A 8p21 tumor necrosis factor receptor superfamily, member 10a LOC389641 8 hypothetical gene supported by AK124295 MGC29816 8p21.2 hypothetical protein MGC29816 LOC203069 8p21.2 hypothetical protein LOC203069 LOXL2 8p21.3-p21.2 lysyl oxidase-like 2 LYSAL1 8p22-p21.3 lysosomal apyrase-like 1 MSCP 8p21.2 mitochondrial solute carrier protein PRO1496 8p21.2 hypothetical protein PRO1496 LOC389642 8 LOC389642 NKX3-1 8p21 NK3 transcription factor related, locus 1 (Drosophila) LOC137814 8p21.2 similar to homeobox protein NKX2-6 STC1 8p21-p11.2 stanniocalcin 1 ADAM28 8p21.3-p12 a disintegrin and metalloproteinase domain 28 ADAMDEC1 8p21.1 ADAM-like, decysin 1 ADAM7 8p21.2 a disintegrin and metalloproteinase domain 7 NEF3 8p22-p21 neurofilament 3 (150kDa medium) NEFL 8p21 neurofilament, light polypeptide 68kDa LOC286061 8p21.2 hypothetical protein LOC286061 DOCK5 8p21.2 dedicator of cytokinesis 5 GNRH1 8p21-p12 gonadotropin-releasing hormone 1 (leutinizing-releasing hormone) KCTD9 8p21.1 potassium channel tetramerisation domain containing 9 CDCA2 8p12-21 cell division cycle associated 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2348 52.7 470 - PMID: 12037602
    15 - 2438 - 391 - PMID: 12037602
    13 - 2229 - 391 - PMID: 12037602
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     intestinelarge intestinecolon highly
    Lymphoid/Immunelymph node   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialabsorptive excretorydigestive epithelium  
    Epithelialbarrier/lininguroepithelium  
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunedendritic cell
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a pro-domain
  • a signal sequence
  • partial lack of a disintegrin domain and total lack of a cysteine-rich domain
  • a furin cleavage site and zinc-binding sites
  • a metalloprotease domain
  • a transmembrane domain, and a variable cytoplasmic tail
  • conjugated MetalloP
    HOMOLOGY
    intraspecies homolog to ADAM15
    Homologene
    FAMILY
  • ADAM (a disintegrin and metalloprotease domain) family
  • reprolysin (M12B) family of zinc metalloproteases
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION
  • playing a role in dentritic cell function and their interactions with germinal center T cells
  • having a similar function as ADAM7 and ADAM28
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    activated by upregulated during dentritic cells maturation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    with MMP12, in bronchoalveolar lavage samples from patients with sarcoidosis, correlating with disease severity
    Susceptibility to venous thromboembolism with high factor VIII levels
    Variant & Polymorphism SNP TGTGG haplotype may indicate an underlying mechanism for high FVIII levels
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS