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FLASH GENE
Symbol ADAM3A contributors: npt/mct/pgu - updated : 03-12-2011
HGNC name ADAM metallopeptidase domain 3a (cyritestin 1)
HGNC id 209
Location 8p11.22      Physical location : 39.308.564 - 39.380.470
Synonym name a disintegrin and metalloproteinase domain 3a (cyritestin 1)
Synonym symbol(s) CYRN1, ADAM3, TMDC1
DNA
TYPE pseudogene
MAPPING cloned Y linked N status provisional
Physical map
LOC389648 8 LOC389648 FLJ14299 8p11.23 hypothetical protein FLJ14299 C8orf2 8p11.2 chromosome 8 open reading frame 2 PROSC 8p11.2 proline synthetase co-transcribed homolog (bacterial) GPR124 8p11.23 G protein-coupled receptor 124 BRF2 8q11.23 BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like RCP 8p11.22 Rab coupling protein MGC33309 8p11.23 hypothetical protein MGC33309 ASH2L 8p11.2 ash2 (absent, small, or homeotic)-like (Drosophila) STAR 8p11.2 steroidogenic acute regulatory protein LSM1 8p11.2 LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae) BAG4 8p11.23 BCL2-associated athanogene 4 KIAA0725 8p11.22 BCL2-associated athanogene 4 HTPAP 8p11.23 HTPAP protein WHSC1L1 8p12-p11.2 Wolf-Hirschhorn syndrome candidate 1-like 1 FLJ25409 8p11.22 hypothetical protein FLJ25409 FGFR1 8p12 fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) LOC389649 8 hypothetical gene supported by AK125570 LOC286140 8p11.22 similar to ring finger protein 5 TACC1 8p11 transforming, acidic coiled-coil containing protein 1 PLEKHA2 8p11.21 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 FLJ90724 8p11.22 hypothetical protein FLJ90724 BLP1 8p11.22 BBP-like protein 1 ADAM9 8p12 a disintegrin and metalloproteinase domain 9 (meltrin gamma) ADAM32 8p11.22 a disintegrin and metalloprotease domain 32 ADAM5 8p11.22 a disintegrin and metalloproteinase domain 5 ADAM3A 8p21-p12 a disintegrin and metalloproteinase domain 3a (cyritestin 1) ADAM18 8p11.21 a disintegrin and metalloproteinase domain 18 ADAM2 8p11.2 a disintegrin and metalloproteinase domain 2 (fertilin beta) INDO 8p11.2 indoleamine-pyrrole 2,3 dioxygenase LOC169355 8p11.22 hypothetical protein LOC169355 C8orf4 8p11.2 chromosome 8 open reading frame 4 FLJ13842 8p11.21 hypothetical protein FLJ13842 SFRP1 8p12-p11.2 secreted frizzled-related protein 1
RNA
TRANSCRIPTS type
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
CATEGORY
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • implicated in mammalian sperm-egg binding
  • having defective zona-binding ability
  • requirement of ADAM2 and ADAM3A in normal sperm association
  • plays a central role in both sperm migration into the oviduct and sperm binding to the zona
  • sperm membrane protein critical for both sperm migration from the uterus into the oviduct and sperm primary binding to the zona pellucida (ZP)
  • principle role of ADAM3A is for sperm migration into the oviduct but not for the fertilization event
  • cysteine-rich, glycosylated membrane protein that is cotranslationally translocated into the endoplasmic reticulum (ER) of spermatids, where numerous molecular chaperones and catalysts promote glycoprotein folding as well as the disposal of misfolded proteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • presence of the ADAM2-ADAM3A complex in sperm suggesting a potential role of ADAM2 with ADAM3A in sperm binding to the egg zona pellucida
  • is a lectin-independent client of CLGN and CALR3
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CLGN is required for ADAM1/ADAM2 dimerization and subsequent maturation of ADAM3A
  • PDILT cooperates with the testis-specific calreticulin-like chaperone, calsperin (CALR3), in the endoplasmic reticulum and plays an indispensable role in the disulfide-bond formation and folding of ADAM3A
  • requires PDILT/CALR3 to be folded properly and transported onto the sperm membrane
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    murine Adam3a-disrupted sperm were unable to migrate into the oviduct after coitus