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FLASH GENE
Symbol ADAM29 contributors: mct - updated : 10-04-2012
HGNC name ADAM metallopeptidase domain 29
HGNC id 207
Location 4q34.1      Physical location : 175.839.508 - 175.899.330
Synonym name
  • a disintegrin and metalloproteinase domain 29
  • cancer/testis antigen 73
  • Synonym symbol(s) svph1 , CT73
    DNA
    TYPE functioning gene
    STRUCTURE 59.82 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC132604 4q34.1 GalNAc transferase 10 isoform-like GALNT7 4q31.1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7) HMGB2 4q31 high-mobility group box 2 SAP30 4q34.1 sin3-associated polypeptide, 30kDa SCRG1 4q31-q32 sin3-associated polypeptide, 30kDa LOC391716 4 similar to 60S ribosomal protein L5 LOC389242 4 LOC389242 HAND2 4q33 heart and neural crest derivatives expressed 2 FLJ11539 4q34.1 hypothetical protein FLJ11539 MORF4 4q33-q34.1 mortality factor 4 LOC391717 4 similar to RAN protein LOC389243 4 LOC389243 FBXO8 4q34.1 F-box only protein 8 KIAA1712 4q34 KIAA1712 HPGD 4q34-q35 hydroxyprostaglandin dehydrogenase 15-(NAD) GLRA3 4q33-q34 glycine receptor, alpha 3 ADAM29 4q34 a disintegrin and metalloproteinase domain 29 LOC391718 4 similar to hypothetical protein MGC2776 GPM6A 4q34 glycoprotein M6A WDR17 4q34 WD repeat domain 17 TSARG2 4q34.2 testis and spermatogenesis cell related protein 2 ASB5 4q34.1 ankyrin repeat and SOCS box-containing 5 FLJ22649 4q34.2 hypothetical protein FLJ22649 similar to signal peptidase SPC22/23 VEGFC 4q34 vascular endothelial growth factor C FLJ10858 4q34.3 DNA glycosylase hFPG2 AGA 4q33-q35 aspartylglucosaminidase LOC285501 4q34.3 hypothetical protein LOC285501 LOC391719 4 similar to hypothetical protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 3244 92 821 - 1999 10512762
    - splicing 2360 - 767 - 1999 10512762
    diverging in 3' region
    - splicing 2300 - 781 - 1999 10512762
    diverging in 3' region
    5 - 3325 - 820 - 1999 10512762
    4 - 3219 - 820 - 1999 10512762
    3 - 3138 - 820 - 1999 10512762
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific
    cell lineage spermatogenic cells
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • domains similar to hemorrhagic snake venom proteins (HSVP)
  • a Zn-binding site metalloproteinase
  • a disintegrin-like domain
  • a cysteine rich domain
  • an EGF-like repeat
  • a transmembrane domain and a cytoplasmic tail
  • conjugated GlycoP , MetalloP
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • ADAM (a disintegrin and metalloprotease domain) family
  • CATEGORY adhesion , enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • a disintegrin and metalloprotease (likely non catalytic), cell surface adhesion protein involved in spermatogenesis
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    often mutated in melanoma, and could play a role in melanoma progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • LPL/ADAM29 expression ratio is a novel prognosis indicator in chronic lymphocytic leukemia
  • Therapy target
    ANIMAL & CELL MODELS