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FLASH GENE
Symbol ADAM28 contributors: mct/pgu - updated : 06-11-2010
HGNC name ADAM metallopeptidase domain 28
HGNC id 206
Location 8p21.2      Physical location : 24.151.579 - 24.212.725
Synonym name
  • a disintegrin and metalloproteinase domain 28
  • metalloproteinase-like, disintegrin-like, and cysteine-rich protein-L
  • epididymial metalloproteinase-like, disintegrin-like, and cysteine-rich protein
  • Synonym symbol(s) EMDC2, MDCLM, MDCL, MDCLS, ADAM23, eMDC I
    EC.number 3.4.24.-
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text clustered with ADAMDEC1 and ADAM7
    STRUCTURE 61.15 kb     23 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC389640 8 LOC389640 TNFRSF10C 8p21 tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain TNFRSF10D 8p21 tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain TNFRSF10A 8p21 tumor necrosis factor receptor superfamily, member 10a LOC389641 8 hypothetical gene supported by AK124295 MGC29816 8p21.2 hypothetical protein MGC29816 LOC203069 8p21.2 hypothetical protein LOC203069 LOXL2 8p21.3-p21.2 lysyl oxidase-like 2 LYSAL1 8p22-p21.3 lysosomal apyrase-like 1 MSCP 8p21.2 mitochondrial solute carrier protein PRO1496 8p21.2 hypothetical protein PRO1496 LOC389642 8 LOC389642 NKX3-1 8p21 NK3 transcription factor related, locus 1 (Drosophila) LOC137814 8p21.2 similar to homeobox protein NKX2-6 STC1 8p21-p11.2 stanniocalcin 1 ADAM28 8p21.3-p12 a disintegrin and metalloproteinase domain 28 ADAMDEC1 8p21.1 ADAM-like, decysin 1 ADAM7 8p21.2 a disintegrin and metalloproteinase domain 7 NEF3 8p22-p21 neurofilament 3 (150kDa medium) NEFL 8p21 neurofilament, light polypeptide 68kDa LOC286061 8p21.2 hypothetical protein LOC286061 DOCK5 8p21.2 dedicator of cytokinesis 5 GNRH1 8p21-p12 gonadotropin-releasing hormone 1 (leutinizing-releasing hormone)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 3220 87 775 . transmembrane form . in spleen, lymph node, and, to a lesser extent, in peripheral blood leukocytes 2010 20544843
  • ADAM28m
  • typical ADAM domain structure, including signal peptide, propeptide, metalloprotease, disintegrin, cysteine-rich, EGF, and transmembrane domains
  • 6 potential N-linked glycosylation sites
  • 14 splicing 2108 - 540 . secreted form . primarily expressed in spleen 2010 20544843
  • ADAM28s
  • having signal peptide, propeptide, metalloprotease, and disintegrin domains identical to those of MDCLM
  • 3 potential N-linked glycosylation sites
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     intestinelarge intestinecolon  
     stomach   highly
    Lymphoid/Immunelymph node   highly
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tracttrachea   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticplasma  highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell Homo sapiens
    cell lineage
    cell lines transformed B and T lymphocytes cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • domains similar to hemorrhagic snake venom proteins (HSVP)
  • a disrupted Zn-binding site metalloproteinase
  • a disintegrin-like domain
  • a cysteine-rich domain
  • an EGF-like repeat
  • a transmembrane domain and a cytoplasmic tail
  • conjugated GlycoP , MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • ADAM (a disintegrin and metalloprotease domain) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text overexpressed in normal memory B cells
    basic FUNCTION
  • putatively involved in sperm maturation
  • may be playing a role in the interaction of lymphocytes with ITGA4B1-expressing leukocytes
  • playing a role in cell proliferation and progression of the lung carcinomas
  • may function as positive regulator of growth and differentiation of dental papilla mesenchymal cells and act as an important molecule mediating reciprocal epithelial-mesenchymal signaling during tooth organ development
  • involved in cell proliferation through enhanced bioavailability of IGFI released from the IGF1/IGFBP3 complex by selective IGFBP3 cleavage in breast carcinomas
  • degrading proteoglycans and may be involved in cartilage degradation in osteoarthritis
  • may promote angiogenesis in the breast carcinoma tissues by releasing vascular endothelial growth factor165 (VEGF165) after digestion of CTGF in the CTGF/VEGF165 complex
  • CELLULAR PROCESS cell life, differentiation
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • ligand for ITGA4B1
  • interact with integrins and is involved in the digestion of IGFBP3 through release of IGF1, a potent inducer of cell proliferation
  • interacting with SELPLG (ADAM28 promotes SELPLG/P-selectin-mediated leukocyte rolling adhesion to endothelial cells and subsequent infiltration into tissue spaces through interaction with SELPLG on leukocytes under inflammatory conditions)
  • also involved in activation of EGFR, MAPK1, MAPK3 and release of CD44
  • CTGF is a novel substrate of ADAM28
  • cell & other
    REGULATION
    activated by activated by MMP-7
    induced by all-trans retinoic acid in primary chondrocytes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    and activated in non-small cell lung carcinomas
    tumoral     --over  
    in an activated form in human breast carcinoma cells
    tumoral     --over  
    in asbestos-related lung cancer-adenocarcinoma
    tumoral     --over  
    predominantly by carcinoma cells in the invasive breast carcinomas and is involved in carcinoma cell proliferation probably through enhanced bioavailability of insulin-like growth factor-I
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS