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FLASH GENE
Symbol ADAM20 contributors: npt/ - updated : 29-01-2004
HGNC name ADAM metallopeptidase domain 20
HGNC id 199
Location 14q24.1      Physical location : 70.989.078 - 71.001.732
Synonym name a disintegrin and metalloproteinase domain 20
EC.number 3.4.24.-
DNA
TYPE functioning gene
STRUCTURE 12.65 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
text structure intronless
MAPPING cloned Y linked N status provisional
Physical map
RPS29P1 14 ribosomal protein S29 pseudogene 1 WDR22 14q24.1 WD repeat domain 22 DDX18P1 14q21.3 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene 1 C14orf114 14q24.1 chromosome 14 open reading frame 114 GALNTL1 14q24.1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1 ERH 7q34 enhancer of rudimentary homolog (Drosophila) SLC39A9 14q24.1 solute carrier family 39 (zinc transporter), member 9 RPL24P3 14q24.1 ribosomal protein L24 pseudogene 3 C14orf162 14q24.1 chromosome 14 open reading frame 162 LOC387994 14 LOC387994 KIAA0247 14q24.1 LOC387994 SFRS5 14q24 splicing factor, arginine/serine-rich 5 SLC10A1 14q24.1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 SMOC1 14q24.1 SPARC related modular calcium binding 1 RPL7AP6 14 ribosomal protein L7a pseudogene 6 SLC8A3 14q24.1 solute carrier family 8 (sodium-calcium exchanger), member 3 LOC387995 14 similar to leucin rich neuronal protein ADAM21P 14q24.1 a disintegrin and metalloproteinase domain 21 pseudogene LOC338914 14q24.1 hypothetical LOC338914 C14orf112 14q24.1 chromosome 14 open reading frame 112 SYNJ2BP 14q22.1-q24.3 synaptojanin 2 binding protein ADAM21 14q24.1 a disintegrin and metalloproteinase domain 21 C14orf55 14 chromosome 14 open reading frame 55 ADAM20 14q24.1 a disintegrin and metalloproteinase domain 20 MED6 14q24.1 mediator of RNA polymerase II transcription, subunit 6 homolog (yeast) TTC9 14q24.1 tetratricopeptide repeat domain 9 MAP3K9 14q24.3-q31 mitogen-activated protein kinase kinase kinase 9 PCNX 14q24.2 pecanex homolog (Drosophila) PTTG4P 14 pituitary tumor-transforming 4 pseudogene LOC387997 14 LOC387997 LOC390492 14 similar to GWSC6486 SIPA1L1 14q24.1 signal-induced proliferation-associated 1 like 1 RGS6 14q24.3 regulator of G-protein signalling 6
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2807 59.5 776 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  specific
cells
SystemCellPubmedSpeciesStageRna symbol
ReproductiveLeydig cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • domains similar to hemorrhagic snake venom proteins (HSVP) with a prodomain
  • a Zn-binding site metalloproteinase
  • a disintegrin-like domain
  • a cysteine-rich domain
  • a putative fusion peptide likely required for sperm-egg fusion
  • an EGF-like repeat
  • a transmembrane domain
  • a cytoplasmic tail
  • conjugated GlycoP , MetalloP
    isoforms Precursor
    HOMOLOGY
    intraspecies homolog to fertilin-alpha
    Homologene
    FAMILY
  • ADAM (a disintegrin and metalloprotease domain) family
  • CATEGORY adhesion , enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • a disintegrin and metalloprotease (active), cell surface adhesion protein involved in sperm maturation and fertilization
  • CELLULAR PROCESS protein, post translation
    protein, degradation
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS