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FLASH GENE
Symbol ADAM2 contributors: mct/pgu - updated : 21-09-2010
HGNC name ADAM metallopeptidase domain 2
HGNC id 198
Location 8p11.22      Physical location : 39.601.255 - 39.695.779
Synonym name
  • a disintegrin and metalloproteinase domain 2 (fertilin beta)
  • fertilin beta
  • cancer/testis antigen 15
  • Synonym symbol(s) FTNB, CT15, PH30, PH-30b, CRYN1, CRYN2
    DNA
    TYPE functioning gene
    STRUCTURE 94.53 kb     21 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    GPR124 8p11.23 G protein-coupled receptor 124 BRF2 8q11.23 BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like RCP 8p11.22 Rab coupling protein MGC33309 8p11.23 hypothetical protein MGC33309 ASH2L 8p11.2 ash2 (absent, small, or homeotic)-like (Drosophila) STAR 8p11.2 steroidogenic acute regulatory protein LSM1 8p11.2 LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae) BAG4 8p11.23 BCL2-associated athanogene 4 KIAA0725 8p11.22 BCL2-associated athanogene 4 HTPAP 8p11.23 HTPAP protein WHSC1L1 8p12-p11.2 Wolf-Hirschhorn syndrome candidate 1-like 1 FLJ25409 8p11.22 hypothetical protein FLJ25409 FGFR1 8p12 fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) LOC389649 8 hypothetical gene supported by AK125570 LOC286140 8p11.22 similar to ring finger protein 5 TACC1 8p11 transforming, acidic coiled-coil containing protein 1 PLEKHA2 8p11.21 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 FLJ90724 8p11.22 hypothetical protein FLJ90724 BLP1 8p11.22 BBP-like protein 1 ADAM9 8p12 a disintegrin and metalloproteinase domain 9 (meltrin gamma) ADAM32 8p11.22 a disintegrin and metalloprotease domain 32 ADAM5 8p11.22 a disintegrin and metalloproteinase domain 5 ADAM3A 8p21-p12 a disintegrin and metalloproteinase domain 3a (cyritestin 1) ADAM18 8p11.21 a disintegrin and metalloproteinase domain 18 ADAM2 8p11.2 a disintegrin and metalloproteinase domain 2 (fertilin beta) INDO 8p11.2 indoleamine-pyrrole 2,3 dioxygenase LOC169355 8p11.22 hypothetical protein LOC169355 C8orf4 8p11.2 chromosome 8 open reading frame 4 FLJ13842 8p11.21 hypothetical protein FLJ13842 SFRP1 8p12-p11.2 secreted frizzled-related protein 1 GCP16 LOC392214 8 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) MGC14799 8p11.21 hypothetical protein MGC14799 DKFZp586M1819 8p11.21 putative lysophosphatidic acid acyltransferase
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 2657 82.3 735 - PMID: 9041139
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    cell lineage spermatogenic
    cell lines renal cancer cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • domains similar to hemorrhagic snake venom proteins (HSVP)
  • a prodomain
  • a Zn-binding site metalloproteinase
  • an inactive disintegrin-like domain
  • a cysteine-rich domain,an EGF-like repeat
  • a transmembrane domain and a cytoplasmic tail
  • conjugated GlycoP , MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • ADAM (a disintegrin and metalloprotease domain) family
  • CATEGORY adhesion , enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • a disintegrin and metalloprotease (inactive), cell surface adhesion protein
  • may be involved in male fertility
  • putatively binding to an unknown receptor on oocyte vitelline membrane
  • implicated in mammalian sperm-egg binding
  • contributes to rostral migratory stream migration, possibly through cell-cell interactions that mediate the rapid migration of the neuroblasts to their endpoint
  • requirement of ADAM2 and ADAM3 in normal sperm association
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
  • presence of the ADAM2-ADAM3A complex in sperm suggesting a potential role of ADAM2 with ADAM3A in sperm binding to the egg zona pellucida
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • CLGN is required for ADAM1/ADAM2 dimerization and subsequent maturation of ADAM3A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • brains from Adam2 knockout (KO) mice showed a smaller olfactory bulb than that seen in wild-type (WT) mice at postnatal day 0