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FLASH GENE
Symbol ADAM18 contributors: npt/ - updated : 17-09-2004
HGNC name ADAM metallopeptidase domain 18
HGNC id 196
Location 8p11.21      Physical location : 39.442.086 - 39.587.583
Synonym name
  • a disintegrin and metalloproteinase domain 18
  • transmembrane metalloproteinase-like, disintegrin-like, and
  • cysteine-rich protein III
    Synonym symbol(s) ADAM27, TMDCIII, AD18, MGC41836, MGC88272, TMDC3
    DNA
    TYPE functioning gene
    STRUCTURE 145.35 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC389648 8 LOC389648 FLJ14299 8p11.23 hypothetical protein FLJ14299 C8orf2 8p11.2 chromosome 8 open reading frame 2 PROSC 8p11.2 proline synthetase co-transcribed homolog (bacterial) GPR124 8p11.23 G protein-coupled receptor 124 BRF2 8q11.23 BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like RCP 8p11.22 Rab coupling protein MGC33309 8p11.23 hypothetical protein MGC33309 ASH2L 8p11.2 ash2 (absent, small, or homeotic)-like (Drosophila) STAR 8p11.2 steroidogenic acute regulatory protein LSM1 8p11.2 LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae) BAG4 8p11.23 BCL2-associated athanogene 4 KIAA0725 8p11.22 BCL2-associated athanogene 4 HTPAP 8p11.23 HTPAP protein WHSC1L1 8p12-p11.2 Wolf-Hirschhorn syndrome candidate 1-like 1 FLJ25409 8p11.22 hypothetical protein FLJ25409 FGFR1 8p12 fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) LOC389649 8 hypothetical gene supported by AK125570 LOC286140 8p11.22 similar to ring finger protein 5 TACC1 8p11 transforming, acidic coiled-coil containing protein 1 PLEKHA2 8p11.21 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 FLJ90724 8p11.22 hypothetical protein FLJ90724 BLP1 8p11.22 BBP-like protein 1 ADAM9 8p12 a disintegrin and metalloproteinase domain 9 (meltrin gamma) ADAM32 8p11.22 a disintegrin and metalloprotease domain 32 ADAM5 8p11.22 a disintegrin and metalloproteinase domain 5 ADAM3A 8p21-p12 a disintegrin and metalloproteinase domain 3a (cyritestin 1) ADAM18 8p11.21 a disintegrin and metalloproteinase domain 18 ADAM2 8p11.2 a disintegrin and metalloproteinase domain 2 (fertilin beta) INDO 8p11.2 indoleamine-pyrrole 2,3 dioxygenase LOC169355 8p11.22 hypothetical protein LOC169355 C8orf4 8p11.2 chromosome 8 open reading frame 4 FLJ13842 8p11.21 hypothetical protein FLJ13842 SFRP1 8p12-p11.2 secreted frizzled-related protein 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 2248 82.7 739 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    cell lineage
    cell lines
    fluid/secretion sperm
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one EGF-like domain
  • one disintegrin domain
  • a putative integrin-binding glu-cys-asp (ECD) motif
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • peptidase family M12B
  • ADAM (a disintegrin and metalloprotease domain) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • sperm surface membrane protein that may be involved in spermatogenesis and fertilization
  • playing a potential role in oocyte recognition
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS