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FLASH GENE
Symbol ADAM11 contributors: mct/np - updated : 07-11-2007
HGNC name ADAM metallopeptidase domain 11
HGNC id 189
Location 17q21.3      Physical location : 42.836.567 - 42.859.212
Synonym name
  • metalloproteinase-like, disintegrin-like, cysteine-rich protein
  • a disintegrin and metalloproteinase domain 11
  • Synonym symbol(s) MPSL1, MDC
    DNA
    TYPE functioning gene
    STRUCTURE 22.00 kb     27 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2900 56.8 524 - Katagiri
    less abundant
    27 - 3160 83.4 769 - Katagiri, Fu (2004)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrain    
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • domains similar to hemorrhagic snake venom proteins (HSVP) with a prodomain
  • a disrupted Zn-binding site metalloproteinase
  • a disintegrin-like domain
  • a cysteine-rich domain
  • an EGF-like repeat
  • a transmembrane (TM) domain and a cytoplasmic tail
  • conjugated GlycoP , MetalloP
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • ADAM (a disintegrin and metalloprotease domain) family
  • CATEGORY adhesion , enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text membrane-anchored proteins structurally related to snake venom disintegrins
    basic FUNCTION
  • a disintegrin and metalloprotease (inactive), cell surface adhesion protein implicated in cell-cell and cell-matrix interactions
  • has only a minor effect on cell growth
  • CELLULAR PROCESS protein, post translation
    protein, degradation
    PHYSIOLOGICAL PROCESS development
    text neurogenesis muscle development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • integrins
  • with ADAM22 and ADAM23, binds LGI1 and LGI4 (LGI-ADAM system seems to be regulated not only by the affinity but also by the cell-type-specific expression of each protein) (Sagane 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in low- and high-grade gliomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS