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FLASH GENE
Symbol ACTR8 contributors: mct - updated : 11-03-2011
HGNC name ARP8 actin-related protein 8 homolog (yeast)
HGNC id 14672
Location 3p21 1      Physical location : 53.901.095 - 53.916.229
Synonym symbol(s) ARP8, FLJ12934, FLJ22579, INO80N
DNA
TYPE functioning gene
STRUCTURE 15.13 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 3629 - 624 - 2010 20971067
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle, interphase
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Actr8
ortholog to yeast nuclear Arp8
Homologene
FAMILY actin family
CATEGORY motor/contractile
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton
intracellular,nucleus,chromatin/chromosome
text
  • accumulates on mitotic chromosomes, on the chromatin
  • both ACTR5 and ACTR8 localize to the nuclei of interphase cells
  • basic FUNCTION
  • structural constituent of cytoskeleton
  • required for the chromatin remodeling activity of the INO80 complex, which may promote recombinational telomere maintenance by altering chromatin structure
  • chromosome-associated ACTR8 has a role in chromosome behavior
  • role at mitotic chromosomes is independent of the activity of INO80 complexes
  • important subunit that is required for the recruitment of the mammalian INO80 complex to the DNA damage sites
  • ACTR8 is required for the recruitment, and ACTR5 is required for the DNA repair functions of the INO80 complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component part of INO80 complex containing three actin-related proteins (ARPs), of which ACTR5 and ACTR8 are specific to the INO80 complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with INO80 (ACTR8 is an important subunit that is required for the recruitment of the mammalian INO80 complex to the DNA damage sites)
  • interactions between the nucleosome histone core and ACTR8 in the INO80 chromatin remodeling complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS