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FLASH GENE
Symbol ACTR2 contributors: mct - updated : 09-07-2019
HGNC name ARP2 actin-related protein 2 homolog (yeast)
HGNC id 169
Location 2p14      Physical location : 65.454.828 - 65.498.385
Synonym name
  • ARP2 (actin-related protein 2, yeast) homolog
  • actin-like protein 2
  • actin-related protein 2
  • Synonym symbol(s) ARP2
    DNA
    TYPE functioning gene
    STRUCTURE 42.56 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D2S2397 - D2S1342 - ACTR2 - D2S2231 - D2S380 - cen
    Physical map
    OTX1 2p13 orthodenticle homolog 1 (Drosophila) LOC51057 2p15 hypothetical protein LOC51057 MDH1 2p16 malate dehydrogenase 1, NAD (soluble) LOC388955 2 similar to Px19-like protein (25 kDa protein of relevant evolutionary and lymphoid interest) (PRELI) (CGI-106) (SBBI12) LOC391377 2 similar to ribosomal protein S4 LOC391378 2 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) UGP2 2p14-p13 UDP-glucose pyrophosphorylase 2 VPS54 2p13-p14 vacuolar protein sorting 54 (yeast) PELI1 2p13.3 pellino homolog 1 (Drosophila) LOC130773 2p15 similar to 60S ribosomal protein L23a HSPC159 2p15 HSPC159 protein FLJ20080 2p15 hypothetical protein FLJ20080 TRIP-Br2 2p15 transcriptional regulator interacting with the PHS-bromodomain 2 SLC1A4 2p13.3 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 LOC200731 2p14 hypothetical LOC200731 KIAA0582 2p14 hypothetical LOC200731 RAB1A 2p14 RAB1A, member RAS oncogene family LOC150984 2p14 similar to voltage-dependent anion channel isoform 2 ACTR2 2p14 ARP2 actin-related protein 2 homolog (yeast) SPRED2 2p14 sprouty-related, EVH1 domain containing 2 LOC388956 2 LOC388956 LOC391379 2 similar to DnaJ homolog subfamily B member 12 LOC391380 2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) MEIS1 2p14-p13 Meis1, myeloid ecotropic viral integration site 1 homolog (mouse) LOC391381 2 similar to DNA cytosine methyltransferase 3 alpha isoform a; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; DNA cytosine methyltransferase 3A2 ETAA16 2p13-p15 ETAA16 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 splicing 3929 - 394 - -
    10 splicing 3944 - 399 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Endocrinepancreas   highly
    Nervousbrain   highly
    Reproductivemale systemprostate  highly
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer
    HOMOLOGY
    interspecies homolog to Drosophila Arp14D
    homolog to C.elegans K17C5.1
    ortholog to Actr2, Mus musculus
    homolog to yeast S.cerevisiae arp2
    ortholog to Actr2, Rattus norvegicus
    ortholog to ACTR2, Pan troglodytes
    Homologene
    FAMILY
  • actin family
  • ARP2 subfamily
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microfilament
    text actin cytoskeleton associated
    basic FUNCTION
  • being essential to cell shape and motility through lamellipodial actin assembly and protrusion
  • ACTR2/ACTR3 is a major nucleator of actin assembly at the zonula adherens (ZA)
  • close relationship exists between ACTR2/ACTR3-mediated actin assembly and myosin-driven contractility at the ZA
  • WASF2–ACTR2/ACTR3 is necessary for myosin II recruitment and tension generation at the zonula adherens
  • CELLULAR PROCESS cell organization/biogenesis
    cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component major constituent of the Arp2/3 complex (composed of ACTR2, ACTR3, P41-ARC, P34-ARC, P21-ARC, P20-ARC and P16-ARC)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to actin
  • interaction between cortactin and ACTR2, ACTR3 complex plays an important role in S1P-mediated remodeling of endothelial cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS