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FLASH GENE
Symbol ACTR1B contributors: mct - updated : 30-08-2008
HGNC name ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
HGNC id 168
Location 2q11.1-q11.2      Physical location : 98.272.401 - 98.280.561
Synonym name
  • actin-related protein 1B
  • beta-centractin
  • ARP1, yeast homolog B
  • Synonym symbol(s) CTRN2, ARP1B, PC3
    DNA
    TYPE functioning gene
    STRUCTURE 7.00 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC93082 2q11.2 hypothetical protein BC012317 MRF-1 FLJ10081 2p12-p11.2 hypothetical protein FLJ10081 LOC391408 2 similar to myoferlin isoform b; fer-1-like 3 LOC90342 2q11.2 similar to fer-1 like protein 3 LMAN2L 2q11.1 lectin, mannose-binding 2-like CNNM4 2p12-p11.2 cyclin M4 LOC130643 2q11.2 hypothetical LOC130643 CNNM3 2p12-p11.2 cyclin M3 DARP MGC41816 2q11.2 hypothetical protein MGC41816 SEMA4C 2q11.1 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C LOC51252 2q11.2 hypothetical protein LOC51252 LOC391409 2 hypothetical gene supported by NM_138800 LOC375247 2q11.2 hypothetical LOC375247 DKFZp434N062 2q11.2 hypothetical protein DKFZp434N062 UNQ2430 2q11.2 ankyrin-related KIAA1641 2q11.2 KIAA1641 protein UBE3AP1 2q11.1 ubiquitin protein ligase E3A pseudogene 1 LOC389008 2 similar to KIAA1641 protein LOC151320 2q11.2 similar to autoantigen NOR-90 COX5B 2cen-q13 cytochrome c oxidase subunit Vb ACTR1B 2q11.1-q11.2 ARP1 actin-related protein 1 homolog B, centractin beta (yeast) RNU4P2 2q11.2 RNA, U4 small nuclear pseudogene 2 (U4/14) LOC130639 2q11.2 hypothetical LOC130639 ZAP70 2q12 zeta-chain (TCR) associated protein kinase 70kDa RW1 2q11.2 RW1 protein MGC26733 2q11.2 hypothetical protein MGC26733 CNGA3 2q11.2 cyclic nucleotide gated channel alpha 3 INPP4A 2q11.2 inositol polyphosphate-4-phosphatase, type I, 107kDa GMH1 MGAT4A 2q12 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme A
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2054 42 376 - Hillier (2005)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Nervousnerve   highly
    Reproductivefemale systemuteruscervix highly
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to yeast actin related protein 1
    intraspecies paralog to ACTR1A
    Homologene
    FAMILY
  • actin family
  • ARP1 subfamily
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    intracellular,nuclear envelope
    basic FUNCTION
  • regulator of cytoplasmic dynein-mediated functions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of the large macromolecular complex, dynactin, actin-like microfilament backbone, required for the cytoplasmic dynein-driven movement of organelles along microtubules
  • involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DCTN1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    might be involved in dendritic cells dysfunction and subsequent hepatocellular carcinoma immune escape
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS