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FLASH GENE
Symbol ACTR1B contributors: mct - updated : 08-12-2020
HGNC name ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
HGNC id 168
Location 2q11.2      Physical location : 98.272.401 - 98.280.561
Synonym name
  • actin-related protein 1B
  • beta-centractin
  • ARP1, yeast homolog B
  • Synonym symbol(s) CTRN2, ARP1B, PC3
    DNA
    TYPE functioning gene
    STRUCTURE 8.11 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2204 42 376 - 2008 17619203
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Nervousnerve   highly
    Reproductivefemale systemuteruscervix highly
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to yeast actin related protein 1
    intraspecies paralog to ACTR1A
    Homologene
    FAMILY
  • actin family
  • ARP1 subfamily
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    intracellular,nuclear envelope
    basic FUNCTION
  • regulator of cytoplasmic dynein-mediated functions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of the large macromolecular complex, dynactin, actin-like microfilament backbone, required for the cytoplasmic dynein-driven movement of organelles along microtubules
  • involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DCTN1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    might be involved in dendritic cells dysfunction and subsequent hepatocellular carcinoma immune escape
    constitutional     --over  
    in Parkinson disease (PD)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS