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FLASH GENE
Symbol ACSL3 contributors: mct - updated : 11-10-2017
HGNC name acyl-CoA synthetase long-chain family member 3
HGNC id 3570
Location 2q34      Physical location : 223.725.731 - 223.808.118
Synonym name
  • acyl-CoA synthetase
  • fatty-acid-Coenzyme A ligase, long-chain 3
  • ligno ceroyl-COA synthetase
  • Synonym symbol(s) ACS3,PRO2194,FACL3
    EC.number 6.2.1.3
    DNA
    TYPE functioning gene
    STRUCTURE 42.00 kb     15 Exon(s)
    regulatory sequence Promoter (CAAT box)
    Binding site   transcription factor
    text structure AP-1,Oct-1,GATAs,SRY,CdxA,NKx-2.5,c-Myb,HSF2,NF-AT,AP-2,NF-Y and p300 binding sites
    MAPPING cloned Y linked N status provisional
    regionally located located between D2S360 and WI-21901
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas     Homo sapiens
    Nervousbrain   highly
    Reproductivemale systemtestis   
     male systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...) Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    25-amino-acid consensus sequence,(FACs signature motif)
    HOMOLOGY
    interspecies homolog to murine Facl3
    Homologene
    FAMILY
  • long-chain-fatty-acid-coenzyme A ligase family
  • ATP-dependent AMP-binding enzyme family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,peroxisome
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • converting free long-chain fatty acid into fatty acyl-CoA esters
  • playing a role in lipid biosynthesis and fatty acid degradation
  • using preferentially myristate,laurate,arachidonate and eicosapentaenoate as substrates
  • involvement of ACSL4 and ACSL3 in insulin secretion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    lipid metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor, nucleotide,
  • magnesium Mg2+
  • AMP
  • protein
    cell & other
    REGULATION
    activated by thyroid hormones
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS