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FLASH GENE
Symbol ACSL1 contributors: mct - updated : 23-04-2012
HGNC name acyl-CoA synthetase long-chain family member 1
HGNC id 3569
Location 4q35.1      Physical location : 185.676.748 - 185.747.215
Synonym name
  • palmitoyl-CoA ligase
  • fatty-acid-Coenzyme A ligase, long-chain 1
  • Synonym symbol(s) LACS, LACS1, FACL1, LACS2
    EC.number 6.2.1.3
    DNA
    TYPE functioning gene
    STRUCTURE 70.47 kb     21 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 3822 - 698 - 1995 7490105
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   predominantly Homo sapiens
    Endocrinepancreas   lowly
    Nervousbrain   lowly
    Respiratorylung   lowly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Connectiveadipose   
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerythroid
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta lowly
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    25-amino-acid consensus sequence,(FACs signature motif)
    HOMOLOGY
    interspecies homolog to C.elegans Y76A2B.3
    Homologene
    FAMILY
  • long-chain fatty-acid-coenzyme A ligase family
  • ATP-dependent AMP binding enzyme family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,peroxisome
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • converting free long-chain fatty acids into fatty acyl-CoA ester
  • playing a role in lipid biosynthesis and fatty acid degradation
  • using preferentially palmitoleate, oleate and linoleate as substrate
  • play a role in facilitating long-chain fatty acid (LCFA) transport in mammalian cells under physiologic conditions
  • primary role in adipocytes not in control of lipid influx, as previously considered, but in lipid efflux and fatty acid-induced insulin resistance
  • essential for the synthesis of triacylglycerol
  • has a specific function in directing the metabolic partitioning of fatty acids toward beta-oxidation in adipocytes
  • required for oleate and linoleate mediated inhibition of cholesterol efflux through ABCA1 in macrophages
  • plays a critical role by promoting the inflammatory phenotype of macrophages associated with type 1 diabetes
  • catalyzes the thioesterification of fatty acids, and monocytes from humans with type 1 diabetes also exhibit increased ACSL1
  • ACSL1 and gelsolin are oppositely regulated in adipogenesis and lipogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    lipid metabolism
    a component
  • CPT1A forms hetero-oligomeric complexes with ACSL1 and VDAC1 and is part of an outer membrane fatty acid transfer complex
  • INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor, nucleotide,
  • magnesium Mg2+
  • AMP
  • protein
  • constitutive interaction between SLC27A1and ACSL1 contributes to the efficient cellular uptake of LCFAs in adipocytes through vectorial acylation
  • strong protein-protein interaction between CPT1A, ACSL1, and VDAC1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS