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FLASH GENE
Symbol ACSF2 contributors: KTN/npt - updated : 25-06-2008
HGNC name acyl-CoA synthetase family member 2
HGNC id 26101
Location 17q21.33      Physical location : 48.503.518 - 48.552.200
Synonym name
  • acyl-CoA synthetase family member 2, mitochondrial
  • PPARG binding, long chain fatty acid acyl Co-A ligase like
    • Synonym symbol(s) FLJ20920, ACSMW, AVYV493
    EC.number 6.2.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 48.00 kb     16 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 2257 68 615 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   predominantly
    Lymphoid/Immunethymus   moderately
    Urinarybladder   moderately
     kidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Acsf2 (78.5 pc)
    Homologene
    FAMILY
  • ATP-dependent AMP-binding enzyme family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • catalyzing the initial reaction in fatty acid metabolism, by forming a thioester with CoA
  • playing a role in adipodyte differentiation
  • having ligase activity
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • fatty acid metabolism
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by PPARG
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS