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FLASH GENE

Symbol

ACPT

contributors: mct - updated : 06-12-2016

HGNC name	acid phosphatase, testicular
HGNC id	14376

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	AIH8 amelogenesis imperfecta 8, hypoplastic
Location	19q13.33      Physical location : 51.293.671 - 51.298.481
EC.number	3.1.3.2

DNA

TYPE	functioning gene
STRUCTURE	4.81 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - ACPT - KLK1 - KLK15 - KLK3 qter
Authors	Yousef

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed ACPT - - 1280 46.1 426 - 2001 11414767 ACPTV3 - splicing 1010 - 333 - 2001 11414767 ACPTV2 - splicing 1210 - ? - 2001 11414767 NM_033068 11 splicing 1347 NP_149059 - 426 - 2001 11414767

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tooth enamel     Homo sapiens Reproductive male system testis     highly

cells

System Cell Pubmed Species Stage Rna symbol Digestive ameloblast Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal signal peptide
	a long extracellular domain (29–390 AAs)
	following the signal peptide (28 AAs)
	a short cytoplasmic domain (415–426 AAs) and transmembrane domain (391–414 AAs)

HOMOLOGY

Homologene

FAMILY

histidine acid phosphatase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
text	single-pass type I membrane protein

basic FUNCTION	hydrolyzing orthophosphoric monoester to alcohol and phosphate
	ACPT inhibits likely cell proliferation through CTNNB1-mediated signaling in dental mesenchyme but elicits odontoblast differentiation and mineralization by supplying phosphate during dentin formation
	crucial function of ACPT during amelogenesis
	functions during the secretory stage of amelogenesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

ACPT is expressed earlier than tissue-nonspecific alkaline phosphatase (ALPL) and partly overlaps with ALPL in differentiating odontoblasts

cell & other

REGULATION

induced by

upregulated by androgens

ASSOCIATED DISORDERS

corresponding disease(s)

AIH8

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in testicular cancers

Susceptibility

Variant & Polymorphism

Candidate gene	might be a novel candidate for inducing odontoblast differentiation and mineralization for dentin regeneration
Marker
Therapy target

ANIMAL & CELL MODELS