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FLASH GENE
Symbol ACP5 contributors: mct/pgu - updated : 17-09-2010
HGNC name acid phosphatase 5, tartrate resistant
HGNC id 124
Corresponding disease
SPENCD1 spondyloenchondrodysplasia with immune dysregulation 1
Location 19p13.2      Physical location : 11.685.476 - 11.689.801
Synonym name
  • tartrate-resistant purple acid phosphatase
  • tartrate-resistant acid ATPase
  • type 5 acid phosphatase
  • Synonym symbol(s) TRAP, TRACP, MGC117378, TrATPase
    EC.number 3.1.3.2
    DNA
    TYPE functioning gene
    STRUCTURE 4.33 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure
  • in the -839/-639promoter region a PARP1 binding site, and transcriptional activity of ACP5, in pre-osteoclastic cells, is negatively regulated by the binding of PARP1 protein to a potential consensus sequence located in its promoter region
  • promoter contains a STAT6-binding motif, and STAT6 bound to the endogenous ACP5 promoter after IL4 treatment
  • MAPPING cloned Y linked N status confirmed
    Physical map
    FLJ90806 KIAA1518 LOC55908 19p13.2 hepatocellular carcinoma-associated gene TD26 TM4-B 19p13.2 tetraspanin TM4-B RAB3D 19p13.2 RAB3D, member RAS oncogene family LPPR2 19p13.2 lipid phosphate phosphatase-related protein type 2 UNQ501 19p13.2 MBC3205 LOC126075 19p13.2 hypothetical protein LOC126075 FLJ35119 19p13.2 hypothetical protein FLJ35119 EPOR 19p13.2 erythropoietin receptor RGL3 19p13.1-p13.2 erythropoietin receptor MGC20983 19p13.2 hypothetical protein MGC20983 PRKCSH 19p13.2 protein kinase C substrate 80K-H DKFZp547J036 19p13.2 hypothetical protein DKFZp547J036 ELAVL3 19p13.2 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C) LOC115950 19p13.2 hypothetical protein BC016816 SITPEC 19p13.2 likely ortholog of mouse signaling intermediate in Toll pathway-evolutionarily conserved CNN1 19p13.2 calponin 1, basic, smooth muscle MGC4549 19p13.2 hypothetical protein MGC4549 ACP5 19p13.3-p13.2 acid phosphatase 5, tartrate resistant LOC390889 19 similar to Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) (38 kDa BFA-dependent ADP-ribosylation substrate) (BARS-38) LOC199692 19p13.2 similar to Zinc finger protein 136 LOC342970 19p13.2 similar to Zinc finger protein 20 (Zinc finger protein KOX13) (DKFZp572P0920) LOC284387 19p13.2 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) LOC390890 19 hypothetical gene supported by AK126753 ZNF441 19p13.13 zinc finger protein 441 ZNF491 19p13.2 zinc finger protein 491 ZNF440 19p13.13 zinc finger protein 440 ZNF439 19p13.13 zinc finger protein 439 LOC388506 19 similar to Zinc finger protein 440
    RNA
    TRANSCRIPTS type messenger
    text Variants 1, 2, 3, and 4 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1640 34.3 325 - PMID: 8618440, PMID: 18410226
  • also called TRACP5b
  • its activity is a marker for osteoclast number and perhaps local or systemic bone destruction
  • 7 - 1663 34.3 325 - PMID: 8618440, PMID: 18410226
  • also called TRACP5a
  • increased in about one third of rheumatoid arthritis (RA) sera
  • may be a measure of systemic inflammatory macrophage burden and disease severity
  • 6 - 1590 34.3 325 - PMID: 8618440
    5 - 1506 34.3 325 - PMID: 8618440
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Lymphoid/Immunespleen   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunedendritic cell
    Lymphoid/Immunemacrophage
    Skeletonosteoclast
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • putative signal sequence of 19 AA
  • two potential glycosylation sites
  • conjugated GlycoP
    mono polymer monomer , dimer
    HOMOLOGY
    interspecies homolog to murine Acp5
    Homologene
    FAMILY
  • metallophosphoesterase superfamily
  • purple acid phosphatase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the conversion of orthophosphoric monoester to alcohol and orthophosphate
  • has an important role in the presentation of antigens to T cells
  • important for polarizing responses in na
  • ve T cells to antigen-presented dendritic cells
  • essential for normal skeletal development, and has an important role in the metabolism of collagen
  • acid phosphatase, having a dual role and involved in the regulation of the biological activity of the bone matrix phosphoproteins osteopontin and bone sialoprotein and the intracellular collagen degradation
  • role in regulating osteoclast migration on post-translationally modified SPP1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • disulfide-linked two-subunit structure
  • INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • two iron Fe2+
  • protein
  • interacting with OPN and BSP
  • link between ACP5 activity and interferon metabolism, emphasizing the importance of the type I interferon response in autoimmunity
  • NFATC1 is a key transcription factor, playing a role in regulating expression of osteoclast-specific downstream target genes such as ACP5 and OSCAR
  • cell & other
    REGULATION
    activated by STAT6 (in the absence of TNFSF11 and osteoclast differentiation, STAT6 binds the ACP5 promoter after IL4 treatment and directly enhances its expression)
    repressed by IL4 (down-regulates expression of ACP5 in mature osteoclasts)
    ASSOCIATED DISORDERS
    corresponding disease(s) SPENCD1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    TRACP(-/-) mice have impaired maturation and defective Th1 responses