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FLASH GENE
Symbol ACP1 contributors: npt/ - updated : 12-07-2004
HGNC name acid phosphatase 1, soluble
HGNC id 122
Location 2p25.3      Physical location : 264.868 - 278.280
Synonym name
  • adipocyte acid phosphatase
  • red cell acid phosphatase 1
  • protein tyrosine phosphatase
  • acid phosphatase of erythrocyte
  • cytoplasmic phosphotyrosyl protein phosphatase
  • low molecular weight phosphotyrosine protein phosphatase
  • LMW-PTPase
  • Synonym symbol(s) PA1F, HAAP, LMW-PTP, MGC3499, MGC111030
    EC.number 3.1.3.2, 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 13.42 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Physical map
    LOC391502 2 similar to Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5) LOC391500 2 similar to Hypothetical protein CBG17025 SNTG2 2p25 syntrophin, gamma 2 FLJ33590 2q37.3 hypothetical protein FLJ33590 LOC285095 2q37.3 hypothetical LOC285095 PDCD1 2q37.3 programmed cell death 1 LOC389091 2 LOC389091 LOC391501 2 similar to Hypothetical protein CBG20540 MGC25181 2q37.3 hypothetical protein MGC25181 SH3YL1 2p25.3 SH3 domain containing, Ysc84-like 1 (S. cerevisiae) ACP1 2p25 acid phosphatase 1, soluble LOC285016 2p25.3 hypothetical protein LOC285016 LOC285018 U43627 similar to Contains similarity to extensin (atExt1) from Arabidopsis thaliana gb LOC391342 2 similar to Hypothetical protein CBG24508 DKFZp434C1714 LOC200493 2p25.3 similar to ENSANGP00000000189 LOC200491 2p25.3 hypothetical LOC200491 LOC391343 2 similar to serine/arginine repetitive matrix 2 LOC388920 2 LOC388920 LOC388921 LOC348719 TPO 2p25-p24 thyroid peroxidase LOC391344 2 similar to LWamide neuropeptide precursor protein LOC391345 2 similar to splicing factor 3a, subunit 2 LOC391346 2 similar to hypothetical protein LOC391347 2 similar to Mucin 2 precursor (Intestinal mucin 2)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 splicing 1568 - 158 - -
    6 - 1568 - 158 - -
    3 - 658 - 112 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus   highly
    Nervousbrain   highly
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerthrocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text pancreas, highly
    PROTEIN
    PHYSICAL PROPERTIES globular
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • low-molecular -weight acid phosphotyrosine protein phosphatase family
  • CATEGORY receptor membrane phosphatase
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • regulating the intracellular concentration of flavin coezyme
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism cofactor
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacted with both SRC and EPHA2, and the interactions increased in EPHA2-overexpressing cells (Fang 2008)
  • cell & other
    REGULATION
    inhibited by sulfhydryl reagents
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to dyslipidemia in obese women
    Variant & Polymorphism other allele B and C increase the risk of dylipidemia
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS