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FLASH GENE
Symbol ACOX3 contributors: mct - updated : 30-08-2008
HGNC name acyl-Coenzyme A oxidase 3, pristanoyl
HGNC id 121
Location 4p15.3      Physical location : 8.368.009 - 8.442.452
Synonym name
  • pristanoyl-CoA oxidase
  • branched-chain acyl-CoA oxidase
  • moderately similar to pristanoyl-CoA oxidase [R.norvegicus]
  • Synonym symbol(s) BRCOX, PRCOX, BRCACox
    EC.number 1.3.3.6
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 74.00 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC389199 4 hypothetical gene supported by BC031673 ABLIM2 4p16-p15 actin binding LIM protein 2 LOC391618 4 hypothetical gene supported by NM_003875 FLJ20356 HTRA3 4p16.1 serine protease HTRA3 ACOX3 4p15.3 acyl-Coenzyme A oxidase 3, pristanoyl FLJ35725 4p16.1 hypothetical protein FLJ35725 FLJ12891 4p16.1 hypothetical protein FLJ12891 GPR78 4p16.1 G protein-coupled receptor 78 CPZ 4p16 carboxypeptidase Z LOC391619 4 similar to ubiquitin-specific protease 17-like protein LOC391620 4 similar to ubiquitin-specific protease 17-like protein LOC391621 4 similar to ubiquitin-specific protease 17-like protein LOC391622 4 similar to ubiquitin-specific protease 17-like protein LOC391623 4 similar to ubiquitin-specific protease 17-like protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 2890 77 700 - Vanhooren (1997)
    17 - 2822 - 624 - Vanhooren (1997)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   lowly
    Lymphoid/Immunespleen   highly
    Reproductivemale systemprostate  highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a peroxisomal C terminal targeting signal (SKL)
  • HOMOLOGY
    Homologene
    FAMILY
  • acyl-CoA oxidase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,peroxisome
    basic FUNCTION
  • branched-chain acyl-CoA oxidase 3, acting on the CoA-esters of pristanic acid and straight chain mono-and dicarboxy fatty acids
  • involved in the desaturation of 2-methyl branched fatty acids in peroxisomes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic , lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS