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FLASH GENE
Symbol ACOX2 contributors: mct - updated : 23-05-2012
HGNC name acyl-Coenzyme A oxidase 2, branched chain
HGNC id 120
Location 3p14.3      Physical location : 58.490.863 - 58.522.929
Synonym symbol(s) ACAOP, BCOX, BRCOX, THCCox, BRCACOX
EC.number 1.3.36.3/ 1.17.99.3
DNA
TYPE functioning gene
STRUCTURE 32.07 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
ARHGEF3 3p21-p13 Rho guanine nucleotide exchange factor (GEF) 3 SPATA12 3p21.2 spermatogenesis associated 12 IL17RD 3p21.1 interleukin 17 receptor D HESX1 3p21.2-p21.1 homeo box (expressed in ES cells) 1 APPL 3p21.1-p14.3 homeo box (expressed in ES cells) 1 ASB14 3p21.1 ankyrin repeat and SOCS box-containing 14 FLJ40427 3p21.2 hypothetical protein FLJ40427 FLJ44290 3p21.2 FLJ44290 protein DKFZp667B1218 3p21.2 hypothetical protein DKFZp667B1218 ARF4 3p21.2-p21.1 ADP-ribosylation factor 4 FLJ34969 3p21.2 hypothetical protein FLJ34969 SLMAP 3p21.2-p14.3 sarcolemma associated protein LOC344797 3p21.2 similar to peptidylprolyl isomerase A FLNB 3p14.3 filamin B, beta (actin binding protein 278) DNASE1L3 3p21.1-p14.3 deoxyribonuclease I-like 3 ABHD6 3p21.2 abhydrolase domain containing 6 RPP14 3p21.2 ribonuclease P (14kD) PXK 3p21.2 PX domain containing serine/threonine kinase PDHB 3p21.1-p14.3 pyruvate dehydrogenase (lipoamide) beta KCTD6 3p21.2 potassium channel tetramerisation domain containing 6 ACOX2 3p14.3 acyl-Coenzyme A oxidase 2, branched chain TU3A 3p21.1 Homo sapiens TU3A protein (TU3A), mRNA. LOC389126 3 LOC389126 FAM3D 3p21.1 family with sequence similarity 3, member D FLJ42117 3p21.2 FLJ42117 protein LOC339902 3p21.2 hypothetical LOC339902 NPCR 3p21.1 nasopharyngeal carcinoma-related protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 2356 - 681 - 1997 9070889
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Nervousnerve   highly
Reproductivemale systemtestis  highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
ReproductiveSertoli cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a peroxisomal C terminal targeting signal (SKL)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,peroxisome
    basic FUNCTION
  • peroxisomal branched chain trihydroxypristanoyl-CoA oxidase
  • acting on the CoA-esters of bile acid intermediates and pristanic acid
  • key regulatory enzyme of the beta-oxidation pathway 2 for side chain oxidation of cholesterol
  • involved in bile acid production, a process that has been associated with both oxidative stress and regulation of triglyceride levels
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic , lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in preeclampsia (PE), but is a shared risk factor for PE and cardiovascular disease
    Susceptibility to preeclampsia and cardiovascular disease
    Variant & Polymorphism other
  • ACOX2 is a shared genetic risk factor for preeclampsia and cardiovascular disease
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS