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FLASH GENE
Symbol ACOX1 contributors: - updated : 29-08-2007
HGNC name acyl-Coenzyme A oxidase 1, palmitoyl
HGNC id 119
Corresponding disease
PNALD adrenoleukodystrophy, pseudoneonatal
Location 17q25.1      Physical location : 73.937.588 - 73.975.515
Synonym name
  • straight-chain acyl-CoA oxidase
  • acyl-coenzyme A oxidase 1, peroxisomal (Palmitoyl-CoA oxidase) (AOX)
  • peroxisomal fatty acyl-CoA oxidase
  • Synonym symbol(s) ACOX, PALMCOX, SCOX, AOX, MGC1198
    EC.number 1.3.3.6
    DNA
    TYPE functioning gene
    STRUCTURE 38.00 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    MAPPING cloned Y linked   status confirmed
    Physical map
    KIAA0195 17q25.3 likely ortholog of mouse ubiquitin-conjugating enzyme E2-230K CASKIN2 17q25.3 CASK interacting protein 2 LOC283989 17q25.3 hypothetical protein LOC283989 LLGL2 17q24-q25 lethal giant larvae homolog 2 (Drosophila) MYO15B 17q25 myosin XVB, pseudogene LOC390815 17 similar to Myosin XV (Unconventional myosin-15) RECQL5 17q25 RecQ protein-like 5 HCNGP 17q25.3 transcriptional regulator protein ITGB4 17q24.3 integrin, beta 4 GALK1 17q24 galactokinase 1 H3F3B 17q25 H3 histone, family 3B (H3.3B) KIAA1753 17q25.3 KIAA1753 protein UNC13D 17q25.3 unc-13 homolog D (C. elegans) WBP2 17q25 WW domain binding protein 2 TRIM47 17q24.q25 tripartite motif-containing 47 LOC201292 17q25.3 hypothetical protein LOC201292 MRPL38 17q23-q25 mitochondrial ribosomal protein L38 FBF-1 17q25.3 Fas binding protein 1 ACOX1 17q25.1 acyl-Coenzyme A oxidase 1, palmitoyl CDK3 17q25 cyclin-dependent kinase 3 EVPL 17q24.2-q24.3 envoplakin SRP68 17q25,1 signal recognition particle 68kDa GALR2 17q25.3 galanin receptor 2 LGICZ 17q25.3 ligand-gated ion channel subunit EXO70 17q25.3 ligand-gated ion channel subunit FOXJ1 17q forkhead box J1 KIAA1917 17q25.3 KIAA1917 protein MGC29814 17q25.3 hypothetical protein MGC29814 DKFZP434P0316 17q25.3 hypothetical protein DKFZp434P0316 PRPSAP1 17q24-q25 phosphoribosyl pyrophosphate synthetase-associated protein 1 SPHK1 17q25.2 sphingosine kinase 1 E2-230K 17q25.1 likely ortholog of mouse ubiquitin-conjugating enzyme E2-230K
    RNA
    TRANSCRIPTS type messenger
    text proteins identical except for the region specific by the alternate exon 3
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 7514 74.5 660 liver Varanasi
  • exon 3II
  • a C-terminal peroxisomal targeting signal SKL
  • exhibits only 50 p100 specific activity toward palmitoyl-CoA
  • as compared to ACOX1B
    - - 7514 74 660 liver Varanasi
    alternate exon 3I
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Respiratorylung   highly
     respiratory tractlarynx  highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
    HOMOLOGY
    Homologene
    FAMILY acyl-CoA oxidase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,peroxisome
    basic FUNCTION
  • acyl-CoA oxidase, medium or long chain, catalyzing the first step of peroxisomal fatty acid beta-oxidation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text betaoxydation
    PATHWAY
    metabolism energetic , lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    FAD
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PNALD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS