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FLASH GENE
Symbol ACOT8 contributors: mct/npt - updated : 17-06-2008
HGNC name acyl-CoA thioesterase 8
HGNC id 15919
Location 20q12-q13.12      Physical location : 44.470.360 - 44.486.035
Synonym name
  • HIV-Nef associated acyl-CoA thioesterase
  • long-chain fatty-acyl-CoA hydrolase
  • palmitoyl-CoA hydrolase
  • peroxisomal acyl-CoA thioesterase 1
  • choloyl-coenzyme A thioesterase
  • Synonym symbol(s) PTE1, HNAACTE, PTE2, hACTE-III, hTE, PTE-2
    EC.number 3.1.2.27, 3.1.2.2
    DNA
    TYPE functioning gene
    STRUCTURE 15.00 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1157 35.9 319 - Yamaori (2007)
    isoform a
    - - 1023 - 107 - -
  • lacks an alternate exon in the coding region compared to variant 1 causing a frameshift
  • isoform b has a distinct C-terminus compared to isoform a
  • 5 - 962 28.2 254 - Yamaori (2007)
  • lacks an alternate in-frame exon compared to variant 1
  • isoform (c) is shorter but has the same N- and C-termini compared to isoform a
  • EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Lymphoid/Immunelymph node   highly
     thymus   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Acot8
    Homologene
    FAMILY
  • C/M/P thioester hydrolase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,peroxisome
    basic FUNCTION
  • involved in fatty acid oxydation
  • acyl-CoA thioesterase activity showing a preference for medium-length fatty acyl-CoAs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with HIV-NEF
  • cell & other
    REGULATION
    Other regulated by peroxisome proliferator, via the peroxisome proliferator-activated receptors (PPARs)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS