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FLASH GENE
Symbol ACOT7 contributors: - updated : 01-12-2005
HGNC name acyl-CoA thioesterase 7
HGNC id 24157
Location 1p36.2      Physical location : 6.324.332 - 6.453.826
Synonym name
  • cytosolic acyl coenzyme A thioester hydrolase
  • brain long-chain acyl CoA thiolester hydrolase
  • Synonym symbol(s) BLACH, BACH, LACH1, ACT, ACH1, CTE-II, MGC1126
    EC.number 3.1.2.2
    DNA
    TYPE functioning gene
    STRUCTURE 130.00 kb     9 Exon(s)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1814 40.4 370 - -
  • differs in the 5' UTR and 5' coding region, compared to variant hBACHb
  • isoform hBACHa has a shorter and distinct N-terminus compared to isoform hBACHb
  • - - 1979 - 278 - -
  • has an alternate 5' UTR and has multiple coding region differences, compared to variant hBACHb
  • isoform (hBACHa/X) differs at the N- and C-termini compared to isoform hBACHb
  • - - 1887 - 315 - -
  • has an alternate 5' UTR and has multiple coding region differences, compared to variant hBACHb
  • isoform (hBACHa/Xi) differs at the N- and C-termini compared to isoform hBACHb
  • - - 1634 41.7 380 - -
    - - 1439 38.9 350 - -
  • differs in the 5' UTR and 5' coding region, compared to variant hBACHb
  • encodes isoform hBACHc which has a shorter and distinct N-terminus compared to isoform hBACHb
  • - - 1423 36.5 329 - -
  • differs in the 5' UTR and 5' coding region, compared to variant hBACHb
  • encodes isoform hBACHd which has a shorter and distinct N-terminus compared to isoform hBACHb
  • EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    two acyl coenzyme A hydrolase domains
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to rattus bach
    ortholog to murine Acot7
    Homologene
    FAMILY acyl coenzyme family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text whole structure cytosolic, suggesting nuclear translocation of the enzyme
    basic FUNCTION
  • can express long-chain acyl-CoA hydrolase activity in multiple intracellular compartments by generating BACH isoforms with differential localization signals to affect various cellular functions that involve acyl-CoAs
  • may play an important physiological function in brain
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
             
    deranged in hippocampus of mesial temporal lobe epilepsy (MTLE) patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS