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FLASH GENE

Symbol

ACOT7

contributors: - updated : 01-12-2005

HGNC name	acyl-CoA thioesterase 7
HGNC id	24157

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p36.2      Physical location : 6.324.332 - 6.453.826
Synonym name	cytosolic acyl coenzyme A thioester hydrolase
	brain long-chain acyl CoA thiolester hydrolase
Synonym symbol(s)	BLACH, BACH, LACH1, ACT, ACH1, CTE-II, MGC1126
EC.number	3.1.2.2

DNA

TYPE	functioning gene
STRUCTURE	130.00 kb     9 Exon(s)

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed hBACHa - - 1814 40.4 370 - - differs in the 5' UTR and 5' coding region, compared to variant hBACHb isoform hBACHa has a shorter and distinct N-terminus compared to isoform hBACHb hBACHa/X - - 1979 - 278 - - has an alternate 5' UTR and has multiple coding region differences, compared to variant hBACHb isoform (hBACHa/X) differs at the N- and C-termini compared to isoform hBACHb hBACHa/Xi - - 1887 - 315 - - has an alternate 5' UTR and has multiple coding region differences, compared to variant hBACHb isoform (hBACHa/Xi) differs at the N- and C-termini compared to isoform hBACHb hBACHb - - 1634 41.7 380 - - hBACHc - - 1439 38.9 350 - - differs in the 5' UTR and 5' coding region, compared to variant hBACHb encodes isoform hBACHc which has a shorter and distinct N-terminus compared to isoform hBACHb hBACHd - - 1423 36.5 329 - - differs in the 5' UTR and 5' coding region, compared to variant hBACHb encodes isoform hBACHd which has a shorter and distinct N-terminus compared to isoform hBACHb

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two acyl coenzyme A hydrolase domains

mono polymer

homomer , dimer

HOMOLOGY

interspecies	ortholog to rattus bach
	ortholog to murine Acot7

Homologene

FAMILY

acyl coenzyme family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus
text	whole structure cytosolic, suggesting nuclear translocation of the enzyme

basic FUNCTION	can express long-chain acyl-CoA hydrolase activity in multiple intracellular compartments by generating BACH isoforms with differential localization signals to affect various cellular functions that involve acyl-CoAs
	may play an important physiological function in brain

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

lipid/lipoprotein

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function           deranged in hippocampus of mesial temporal lobe epilepsy (MTLE) patients

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS